Since he arrived in England, the former FC Porto head coach has taken the club from winning the Championship to back-to-back seventh-placed finishes in the Premier League whilst also leading them to the quarter-final of the UEFA Europa League last season.
We take a look at what a crop of the players sold by Wolves since May 2017 are now doing with themselves since they departed.
In his first transfer window as boss, Espirito Santo brought Ryan Bennett, Roderick Miranda, Barry Douglas, Ruben Neves, John Ruddy, Oskar Buur to the club, leaving space for players to depart.
George Saville- Sold to Millwall
His debut came in a 3-1 victory over Blackburn Rovers at the end of August before starting the next game in the 0-0 away draw with Blackpool. Further appearances against Charlton Athletic, Bolton and Reading were the final outings for the club until November.
Saville fell out of favour at Molineux and was sent out on loan to League One side Bristol City, where he made seven league appearances and scored in the 3-0 away win at Yeovil Town.
The following season saw Saville remain out of the first-team plans, resulting in a return to Millwall on a 28-day emergency loan. After returning to Wolves, he appeared in the final 18 games as the Wanderers secured 14th in the Championship.
After making 30 appearances in the 2016/17 campaign, Saville joined Millwall on a permanent deal before moving to Middlesbrough on loan in August 2018.
Neves' arrival didn't help Saville and his move to Riverside was made permanent in January 2019, where has over 100 appearances and 11 goals.
Jed Wallace- Sold to Millwall
Wallace joined Wolves in May 2015 after scoring 17 goals in 50 appearances at Portsmouth in the 2014-15 campaign. The winger was sent out on loan to Millwall the following January for the end of the season.
He returned from The Den to appear in six of the opening seven league games, but only managed to appear three more times before heading back to Millwall for another loan spell.
The Lions were promoted via the play-offs, defeating Scunthorpe United and Bradford City to return to the Championship, with Wallace scoring three goals in 19 league appearances.
Millwall made the loan move permanent at the same time as Saville, where he remains now with over 150 appearances.
Jón Daði Böðvarsson- Sold to Reading
Böðvarsson helped Iceland defeat England in the 2016 European Championships prior to his move to Wolves. His debut was marked with a goal against Rotherham United, becoming the 1,000th player to appear in a league game for the Wanderers.
A single goal against Birmingham City and Bristol City saw him become a fan favourite at the club before he switched alliances for Reading. At the Majewski Stadium, he made 56 appearances and scored 16 goals.
Two years ago, he signed for fellow Championship side Millwall, where he remains. Their main striker at the moment as they remain in the battle for the play-offs.
Dave Edwards- Sold to Reading
Over 300 appearances in gold. Two promotions and 44 goals. Edwards said goodbye to Molineux to put pen to paper on a two-year deal with Reading.
Edwards only made 35 appearances for the Royals before re-joining Shrewsbury Town at the start of 2019 on a two-and-a-half-year contract. His second debut for the Shrews four days later, a 3-0 defeat to Charlton.
The midfielder has only appeared for Wales once since departing Wolves, playing 62 minutes in a 1-1 draw with Panama.
He remains a first-team regular at New Meadow as they continue to fight for their League One survival.
Nouha Dicko- Sold to Hull City
Former-Mali international scored 35 goals in 108 appearances during his time in the Black Country after previously enjoying a short loan spell at the club in 2013.
His 18 goals in 24 matches in League One were pivotal to the Wanderers returning to the second tier of English football, before being the club's joint-top goalscorer the following season as they missed out on play-offs on goal difference.
A knee ligament injury kept him out of action until October 2016, over 13 months since his last appearance. His final Wolves goal came against Hull City, the team he departed for.
Dicko only managed four goals for the Tigers in his first season before failing to cement his place in the side, featuring only 19 times in all competitions in the 2018/19 campaign.
After again struggling to strive for Grant McCann's side, he was sent out on loan to Eredivisie side Vitesse, missing only two games and scoring four times.
The 30 June 2020 saw Dicko leave Hull for good and he nows play in the Turkish Super Lig for Gaziantep. Since his move to Turkey, he has had Coronavirus, a disrupted calf muscle and scored three goals.
Jack Price- Sold to Colorado Rapids
The hard-working central midfielder progressed through the Wolves academy before starting to represent the first time in the 2013/14 campaign, making his senior debut in a 4-0 victory against Gillingham.
Tommy Rowe and Saville's arrival at the club saw Price slip down the pecking order in the 2014/15 campaign, forcing the midfielder out on loan to Yeovil Town. A month later, he joined Leyton Orient on a three-month loan before returning to Wolves at the end of 2014.
Both Walter Zenga and Paul Lambert opted not to utilise the Shrewsbury-born player before Nuno let him depart for Colorado Rapids in the Major League Soccer.
Two months after arriving in America, he featured in his first league game, having a penalty saved by Matt Turner against the New England Revolution.
Price replaced Tim Howard as captain after the goalkeeper retired and he received an MVP in the clubs' 2020 End of Season Awards.
Lee Evans- Sold to Sheffield United
Born in Newport, Lee Evans joined the Wanderers from Newport County after helping the club regain its Football League status after a 25-year absence.
Originally in the development squad, Jackett promoted the midfielder to the first team as the club were in League One, with Evans collecting over 25 appearances.
Like Price, the summer arrivals of Saville and Rowe gave Jackett decisions to make in midfield. Despite featuring in 15 of the opening 17 games, Evans was only utilised another three times.
Loan spells at Bradford City and Wigan Athletic put him in the shop window and Sheffield United paid around £750,000 for his services. However, only a year later, he re-joined Wigan permanently.
James Henry departed Wolves after three years at Molineux to join Oxford United, where he remains. A Portugeuse representative that many people may be unaware of, Silvio's contract wasn't renewed. Since leaving England, the full-back has enjoyed spells at Braga B, Vitoria de Setubal, Vitoria S.C and Vitoria Guimaraes, who he joined in 2020.
Former Newcastle United defender, Mike Williamson originally joined Wolves on loan before joining permanently. However, he mustered only six appearances and was released. Like Henry, he spent the 2017/18 campaign with Oxford before becoming player-manager of Gateshead.
Wolves were Andy Lonergan's ninth club when he signed in 2016. The goalkeeper only spent one season at Molineux, making 11 appearances. He followed the pattern of one season stints at clubs, with Leeds United, Middlesbrough, Liverpool, Stoke City and now West Bromwich Albion.
Following promotion to the big time, Wolves saw a host of players arrive in England as they looked to cement themselves as a Premier League side. Players like Willy Boly, Diogo Jota, Ruben Vinagre, Joao Moutinho, Adama Traore, Jonny and Raul Jimenez all helped guide Wolves to seventh.
Duckens Nazon- Sold to Sint-Truiden
Nazon joined Wolves in January 2017, playing for the under-23 team. The following summer he spent the first half of the 2017/18 campaign on loan at League Two side Coventry City before spending the remainder of the season at Oldham Athletic- scoring six goals in 16 appearances.
Despite never playing for the Wanderers' first team, Nazon was signed by Belgium Pro League side Sint-Truiden for an undisclosed fee. His only goal in his debut season came in the 3-0 home victory over KFC Duffel in the Croky Cup.
January 2019 saw him spend the remainder of the season at St Mirren, scoring one goal. On his return to Belgium, the Haiti international only appeared on the final day of the season, a 23-minute cameo at Standard Liege.
However, this season has been his most prolific with six goals in 21 appearances as Sint-Truiden sit just above the relegation zone.
Ben Marshall- Sold to Norwich City
Marshall joined Wolves from fellow Championship side Blackburn Rovers after over 100 appearances at Ewood Park, joining up with his former manager Lambert, who managed him at Blackburn.
However, the move didn't ever work out for the winger, as only a year later, he was sent out on loan to Millwall before signing a four-year contract at Norwich City.
His troubles continued, with Norwich cancelling his contract by mutual consent. He was signed by 12-tier side Stoneclough FC.
Prince Oniangue- Sold to SM Caen
Born in Paris, Oniangue came through the Rennes academy before playing for four different teams in France before joining Wolves in 2016 under Lambert.
The midfielder made 11 appearances for the Wanderers in the first half of the 2016/17 season before joining SC Bastia on loan, where he appeared 14 times and scored three goals.
Following his return to the West Midlands, Oniangue only went on to feature for the under-23s, in defeats to Aston Villa and Middlesbrough. From January 2018, he joined Angers SCO on loan for the second time of his career before signing for SM Caen in the summer of 2018.
The 32-year-old has missed only four games of the 2020/21 season as Les Vikings sit mid-table in Ligue 2.
Barry Douglas- Sold to Leeds United
The Glasgow-born left-back made the unusual route to reach the top after featuring for Lech Poznan in Poland and Konyaspor in Turkey before arriving in England.
Nuno signed Douglas for an undisclosed fee to fit into his system. His performances didn't go unnoticed, being nominated for the Championship Player of The Month in November.
Wolves secured the title and Douglas contributed five goals and 14 assists, joint-top with Robert Snodgrass with an assist in the league.
After promotion to the Premier League, Douglas was sold to Leeds United where he was involved in another promotion bid, this time falling at the last hurdle as the Whites were dramatically defeated by Derby County in the play-offs. However, Douglas only played 27 games due to a series of injury problems such as a ruptured knee ligament.
Last season, he started as Marcelo Biesla's first-choice left-back before another injury spell saw Gjanni Alioski feature more. After being suspended for Leeds' first four games in the Premier League, he was sent on loan to Blackburn, where he starts regularly for Tony Mowbray's side.
Benik Afobe- Sold to Stoke City
Wolves reportedly paid £2 million for Afobe's services in January 2015, finishing the season with 13 goals in 21 games. His goals since arriving at Wolves saw interest from Norwich in the Premier League, but the forward was not allowed to leave in the summer.
The following January saw more interest, with AFC Bournemouth paying £10 million for him as head of football development and recruitment Kevin Thelwell told fans: "Benik was no longer player for us."
Afobe notched in four goals in 15 appearances for the Cherries before scoring six in 31 in the 2016/17 campaign. After struggling to cement his place in the side, Afobe returned to Wolves initially on loan before signing back permanently.
In an unusual turn of events, Afobe was on the road yet again as Stoke City signed him on loan with an obligation to purchase him for £12 million. A year later he spent the 2019/20 season at Bristol City before joining Turkish side Trabzonspor.
Danny Batth- Sold to Stoke City
Central-defender Batth joined Wolves at 15, captioning the youth team before signing a professional contract in 2009. Loan spells at Colchester United, Sheffield United and Sheffield Wednesday matured him before returning to Molineux at the start of the 2012/13 season.
Over 200 appearances at the club, Batth was pivotal to the side that helped the club back to the Championship in 2013/14 and was the longest-serving player when he finally departed the club.
Middlesbrough signed the defender on loan for the start of the 2018/29 season before Stoke swooped to sign him permanently, joining Afobe at the Potteries.
Ben Stevenson- Sold to Colchester United
A rather unknown man in this list, Stevenson was signed by Wolves in January 2018 from Coventry.
Immediately loaned out to Colchester, he scored on his debut in the 2-0 victory over Newport. In the summer of 2018, Stevenson joined Sylvain Deslandes, Will Randall, Ming-yang Yang, Ryan Leak, Aaron Simpson, Boubacar Hanne, Donovan Wilson and Jack Ruddy to join Wolves' Spanish affiliate club Jumilla, where he made 15 appearances.
However, Colchester signed Stevenson again on a permanent deal, where he remains.
Dominic Iorfa- Sold to Sheffield Wednesday
Whilst in League One with Wolves, Iorfa spent the last half of the 2017/18 campaign on loan at Shrewsbury, making seven appearances before returning to Molineux.
He made 20 appearances in gold as they remained in the Championship before becoming a key part of the team in the 2015/16 season as a right-back.
Iorfa's versatility to be able to play in the centre of defence meant he was faced with more appearances in the first half of the next season, before only featuring four more times in the final 24 games.
His lack of football resulted in him joining fellow Championship side Ipswich Town where he made 23 appearances. Iorfa was not utilised in the Premier League and he was sold to Sheffield Wednesday.
In the 2019/20 season, he was voted as the clubs Player of the Year award before rupturing his Achilles, forcing him to miss the remainder of the current season.
Ashley Harris-Sealy was released by Wolves in the summer of 2019 and joined Farnborough after enjoying the second half of the 2017/18 season with the club. In January of this year, the forward signed for National League South side Dulwich Hamlet, where his season has been cut short.
As Wolves prepared for a European tour, that started in July, there were more new faces in the dressing room. Jimenez's loan move was made permanent, Leander Dendoncker signed from Anderlecht, Patrick Cutrone joined from AC Milan and Pedro Neto and Daniel Podence both arrived to see more players shifted.
Ethan Ebanks-Landell- Sold to Shrewsbury Town
A product of the Wolves academy, the central defender enjoyed loan spells at Bury (twice), Sheffield United, MK Dons and Rochdale before finally saying his goodbyes to Molineux in 2019 after 54 appearances.
All the loan spells he had spent away from the Black Country had put the defender in good light for a permanent move and it finally landed in Shropshire.
Then-Salop manager Sam Ricketts brought him to the League One club and he has only missed 10 of his 77 appearances in the English third tier, scoring only two goals.
Kortney Hause- Sold to Aston Villa
Following his release from West Ham at the age of sixteen, centre-back Hause signed for Birmingham City as a scholar before signing youth team forms with Wycombe Wanderers in 2012.
His performances for the Chairboys caught Wolves' recruitment team eye and he was signed in the January transfer window in 2014 and made seven appearances for the U23s side.
After 17 times for the Wanderers as a left-back in the Championship, Gillingham signed the defender on loan for the rest of the 2014/15 campaign before becoming a common face in the Molineux dressing room.
Espirito Santo's arrival seemed to put an end to his time at Wolves, with the defender only appearing once as they stormed the division and returned to the Premier League.
Aston Villa signed him on loan as they looked to return to the top flight, where he appeared 11 times before signing permanently at Villa Park after they defeated Derby in the play-off final.
Pedro Goncalves- Sold to Famalicao
The one that got away for Wolves. Labelled the 'next Bruno Fernandes', he signed from Valencia in 2017. Goncalves made only one appearance for the club (a 28-minute cameo in a 2-0 victory over Sheffield Wednesday in the EFL Cup).
Only a year later, the attacking midfielder returned to Portugal after a previous spell with Braga in his youth days and signed for Famalicao, the now Wolves affiliate club.
In all competitions, Goncalves made 40 appearances, scored seven goals and created eight as Vila Nova missed out on Europa League football by one point.
His performances in Liga NOS attracted interest by the countries best and Sporting CP secured the services of the playmaker. Despite catching coronavirus in September, Goncalves recovered to score 10 goals in six games to help the club sit top of the Portugeuse top division.
Sherwin Seedorf- Sold to Motherwell
Former Nike Academy winger made zero appearances for the first team at Wolves but did appear 17 times for the clubs under-23s whilst at the club.
He did spend the 2018/19 campaign on loan at Bradford City and FC Jumilla before joining Motherwell on a two-year contract.
Scoring on his debut in the Scottish League Cup against Queen of the South, he has made 42 appearances since his move to Scotland.
Ivan Cavaleiro- Sold to Fulham
A product of the famous Benfica youth system, Cavaleiro was part of the club's domestic treble in 2013/14 before playing for Deportivo La Coruna and Monaco before signing for Wolves back in 2016 for a then-club-record of £7 million.
After helping the Wanderers back to the Premier League as champions, the winger scored on his first game in the top division in the 2-0 home win over Southampton with his very first touch.
The winger fell out of favour with the XI at Molineux, he joined Fulham on a season-long loan before agreeing to move to the London-based team permanently in January 2020.
His 18 appearances last season were pivotal to the Cottagers' promotion to the Premier League and he has scored three goals as Scott Parker's side look to hold their top-flight status for next season.
Sylvain Deslandes- Sold to Arges
The Cameroon-born left-back moved to Wolves in 2015 from Caen, but only made three appearances in his first season- all in the final five games of the season.
Deslandes joined Bury in League One in 2017 but failed to make any appearances before making two appearances for Portsmouth in the same division.
Like stated above, Deslandes signed for FC Jumilla in Spain, playing a centre-back. After a proposed loan move to Bulgarian side Lokomotiv Plovdiv fell through due to failing to receive necessary FIFA clearance, the full-back signed for Romanain club Arges Pitesti, where he remains.
Bright Enobakhare- Sold to AEK Athens
The Nigerian striker made 49 appearances for Wolves during his five year spell at the club after signing for the club's academy from Northfield Town.
During his time at Wolves, Enobakhare spent time on loan at Kilmarnock, Coventry and Wigan Athletic before leaving Wolves by a mutual agreement.
Greek club AEK Athens confirmed the signing of the striker in June 2020 and he scored on his debut against Lamia, his only appearance for the club as he mutually solbed his contract.
A year without football and Enobakhare found his new club in Indian Super League side SC East Bengal. Like he did in Greece, he scored on his debut followed by a spectacular solo goal.
There was a number of youth players who departed the club in the summer of 2019, including Aaron Crabtree, Ray O'Sullivan, Taylor Townsend, Ben Goodliffe, Aaron Hayden and Diego Lattie.
Dominican Republic-international Carlos Heredia was released and signed for Polish team Miedź Legnica, but has since left the side. Michal Zyro was at Wolves for three years but only made 10 appearances and later joined Korona Kielce. Since then, the winger has appeared for Stal Mielec and Piast Gliwice.
Burgos recruited both Ryan Leak and Donovan Wilson. Leak remains with the Spanish side whilst Wilson has since returned to England to represent Macclesfield Town, Bath City and Sutton United (his current club).
Scottish goalkeeper Jack Ruddy enjoyed a short spell with Ross County in 2019 before moving to Leganes B team in Spain. He currently plays for Plymouth Argyle, where has made only two appearances.
Another goalkeeper who left the club on a free transfer was Jack Atkinson who signed for Bangor City and is now at Welsh side Prestatyn.
Former Liverpool academy midfielder Paulinho never appeared for Wolves before signing for Czech-side Pribram. He now finds himself back in his home nation, Portugal, representing Sanjoanense.
Harry Burgoyne was signed by Shrewsbury, where he remains, whilst Flavio Cristovao was snapped up by Juniors OO of Austria. He since departed to Portugal, where he now plays for C.S. Maritimo B team.
Now to the current season. Wolves currently (following the recent 3-2 defeat to West Ham) sit 14th in the table after a season full of carnage, unusual defending and a lack of goals in a transitional year for the club.
Helder Costa- Sold to Leeds United
Similar to Cavaleiro and Fulham, Costa joined Leeds on loan in 2019 before signing permanently this summer.
The now-Angola representative helped Leeds return to the top flight as they stormed the second division last season, contributing to 10 goals in 43 appearances.
Grabbing an assist and a goal in his first two games in the Premier League, the winger has made 19 appearances and is a regular face in the Whites squad.
Will Norris- Sold to Burnley
Goalkeeper Norris is one of the unknown players to rise from non-league, starting at Royston Town before signing for Cambridge United. In 2017, Wolves signed the goalkeeper and he made his Premier League debut in April 2019, replacing Rui Patricio in injury time.
He made 20 appearances for Ipswich Town in the 2019/20 campaign before Burnley paid an undisclosed fee for his services. With Nick Pope the number one for Sean Dyche's side, Norris has made only one appearance, a FA Cup tie with MK Dons.
Matt Doherty- Sold to Tottenham Hotspur
Right-back said goodbye to Wolves after 10 years at the club last summer as Jose Mourinho signed him to improve on Serge Aurier.
Doherty scored four league goals in each of his final four campaigns at Molineux, with his contribution from right wing-back one of the most effective of how Wolves played since Nuno arrived.
However, in over 25 appearances in four competitions, Doherty is yet to find the back of the net, whilst only assisting two in the league. It remains a mixed season for the Irishman, with Aurier and himself struggling to set their name in stone in Mourinho's side.
Diogo Jota- Sold to Liverpool
Another player that Wolves fans' were gutted about when he left the club. After 131 appearances, 44 goals and 19 assists, Jota left Wolves and joined raining champions of the Premier League Liverpool for £41 million.
After being an unused substitute in Wolves' 2-0 opening weekend win over Sheffield United, Jota netted five times in his opening nine league games for Jurgen Klopp's side.
However, the Portugal international suffered a bruised knee and missed the end of 2020, only just returning. He scored the winner on his return to Molineux and also contributed to another two goals in their recent 3-0 win at Arsenal.
After over five years at the club, Coventry-born Jordan Graham finally found himself a new home in the summer, joining Gillingham after a successful loan spell.
Connor Johnson, Ming-yang Yang, Phil Ofosu-Ayeh, Todd Parker and Callum Thompson all were released, with Tsun Dai (Shenzhen), Elliot Watt (Bradford City), Boubacar Hanne (Gil Vicente) all departed the club with only one first-team appearance- Watt's only game in the EFL Cup.
Cameron John joined Doncaster Rovers and has featured in most of their League One games this season. Former Arsenal and Tottenham academy striker Benny Ashley-Seal left the club to join Northampton Town and Hungarian Daniel Csoka has 20 appearances for AFC Wimbledon.
Following his loan spell with Leicester City, Ryan Bennett is attempting to help Swansea City back to the Premier League, whilst Niall Ennis has scored five league goals for Plymouth since his January move.
Jon Kitolano returned to his native home Norway in January, whilst Terry Taylor made the jump to professional football and joined Jimmy Floyd Hasselbaink.