With the visitors out of the UEFA Europa League, the only way for them to get into the Champions League next season is with a top four finish, and the competition for that position is heating up as we head into the last few months of the campaign.
Newcastle, meanwhile, are in a relegation battle at the bottom of the table, currently fighting to maintain their Premier League status.
Ahead of the game, now is as good of a time as ever to look back at the last five meetings between the two teams.
Newcastle United 1-2 Tottenham Hotspur – 11 August 2018
Spurs travelled to St. James' Park on the first weekend of the season knowing that they had won four of their last five visits away to their Northern opponents.
Three goals in the opening 20 minutes of the game ultimately decided the contest for the visitors.
Defender Jan Vertonghen gave Tottenham an early lead before Newcastle equalised minutes later through Spanish forward Joselu.
Dele Alli grabbed the winner soon after, though, securing an opening day victory for his side.
Tottenham Hotspur 1-0 Newcastle United – 02 February 2019
Spurs were in their temporary home of Wembley Stadium for the return fixture during the 2018/19 season.
The hosts managed to do the double over the Magpies after a late goal from Heung-min Son sealed all three points for the hosts.
Tottenham Hotspur 0-1 Newcastle United – 25 August 2019
Mauricio Pochettinho’s 500th game as a manager ended in defeat as Newcastle took all three points on this occasion.
This was the visitors' first win in their last 16 league away games against ‘big six’ opposition.
The only goalscorer on the afternoon was Joelinton, who became the third Brazilian to score for the Magpies in the Premier League.
His first-half strike was the only goal on the day as Newcastle managed to hold on for the win.
Newcastle United 1-3 Tottenham Hotspur – 15 July 2020
Son opened the scoring for Tottenham in the 27th minute, and they took that lead into the break.
Matt Ritchie equalised for the hosts in the second half as the Magpies looked to mount a comeback, but two goals from Harry Kane secured the victory for his side instead.
The result meant that Spurs had won three games in a row at St. James' Park in all competitions for the first time since January 1975.
Tottenham Hotspur 1-1 Newcastle United – 27 September 2020
This was another early-season Premier League match that was spoiled by VAR controversy.
Tottenham took the lead in the first half after a goal from Lucas Moura, and that looked like it would be enough for them to win the game.
However, in 93rd minute, Newcastle were awarded a penalty after a handball was called on Eric Dier despite his hand being behind his head at the point of contact..
After a long and extensive VAR check, Callum Wilson converted from the spot in the 97th minute to steal a point for the Magpies.
With both teams needing something from this game, Sunday's contest could be a good one.