The Wanderers travel to Craven Cottage hoping to wound Fulham's survival hopes with seven games remaining of the campaign. Fulham have only managed one victory in their previous six games, losing their previous three.
Ahead of the game, VAVEL goes back in time and look at three classic meetings between the two sides.
Fulham 0-1 Wolves, 20 August 2014
Kenny Jackett's Wolves travelled to Fulham on a Wednesday night after starting the season with a 1-0 win over Norwich City and a 1-0 defeat to Rotherham United.
Against a side that included six players aged 21 and under, Wolves didn't really struggle in London and earned their first victory at Craven Cottage since 1999.
Bakary Sako punished the Whites for failing to deal with a corner, firing the ball past Jesse Joronen after only 15 minutes.
The game was the start of a seven-game unbeaten run, which eventually ended at home to Huddersfield Town in October.
Fulham 0-3 Wolves, 29 September 2015
Fast forward a year later and Wolves travelled to Fulham in a completely different fashion, with only two wins in the opening nine games. Under Kit Symons, Fulham hosted Wolves with three wins in their previous four outings.
Andy Lonergan was on fine form in the first half, denying Benik Afobe and James Henry before the game's first talking point occurred after 35 minutes.
Tom Cairney was dismissed for a two-footed tackle on striker Adam Le Fondre leaving Fulham with 10-men with under an hour remaining of the contest.
The striker then got his name on the scoresheet with the faintest of touches from Sheyi Ojo's strike beat Lonergan to open the floodgates for the Wanderers.
Ojo then scored himself three minutes later when his powerful strike was too much for Lonergan to keep out, creeping in at the front post to put the game to bed.
On 78 minutes Henry curled in a beautiful free-kick from the edge of the area to secure the three points on a rather easy evening for Wolves.
Fulham 1-3 Wolves, 18 March 2017
The Wanderers travelled to play-offs chasers Fulham only two points clear of the relegation zone and looking to add to their back-to-back victories prior.
Cavaleiro opener came just after the half-hour mark courtesy of brilliant wing play by Helder Costa opened up the Fulham defence and provided him with an open net to tap the ball into.
Weimann made it 2-0 in the second half when Conor Coady's cross from the right was delicately touched before smashed into the back of the net by the Austrian forward.
However, Denis Odoi halved the deficit seven minutes later with a long-range deflected effort that left Carl Ikeme scrambling across his goal line.
Paul Lambert's side made sure of the victory in the final 20 minutes with a replica of Cavaleiro's goal. Costa's drive into the Fulham box wasn't dealt with and the Portugeuse winger put the ball in the six-yard box for Edwards to tap into the empty net.