A marginal win was needed as Arsenal look to travel to the Czech Republic in a week's time. However, a 1-1 draw is all that was achieved.
The Gunners had a number of chances to score a number of crucial goals, but only one was bagged.
The similar feeling of frustration and disappointment was felt again, especially with Arteta. Again, the Spaniard was let down.
But what can we take away from Thursday night's display?
Chances not taken
Arsenal easily could have been going to the Sinobo Stadium was a promising lead. However, the continuation of poor finishing hugely damaged their chances to punish the Czech side.
Bukayo Saka was an important aspect to Arsenal's attacking focus, coming back from injury to support their out-of-form forward game.
Although the Englishman has been impressive this season, his finishing was hugely disappointing. A fantastic chance came in the first half, driving from the right hand side, placing a one-on-one opportunity dreadfully wide.
As well as Saka, Alexandre Lacazette missed the biggest chance of the game. With all the time in the world, a free 50 yard run, with only the keeper to beat, the Frenchman clipped the bar.
Although Pepe secured an all important European goal, the Gunners need to be more clinical in the second leg.
If the Gunners want any chance of progressing into the semi-finals, they must take their opportunities in-front of goal.
The introduction of 'Auba', Pepe, and Gabriel Martinelli certainly improved Arsenal's attacking purpose in the second half, which may be an aspect of Arsenal's hunt for an away goal in Prague.
Success down the right hand side
Although there were many negatives from Thursday nights draw, Arsenal used their right hand side effectively as Kieran Tierney was missed from the left.
Although Saka was poor in-front of goal, throughout the entire night he was playing with the defensive ability of Jan Bořil.
As we have seen before, his ability to drive and take on full backs is exceptional, as well as creating chances that unfortunately were not taken.
The winger was replaced by the Ivorian Pepe after 78 minutes, who had the biggest impact as an Arsenal player, opening the scoring in north London.
His instant link up play with Aubameyang and Bellerin created another big scoring chance which was scuffed by 'Auba'.
It is important that the Gunners develop attacks down the right successful due to the injury of Tierney.
Bellerin potentially coming to form may be huge in terms of partnering up with either Saka or Pepe in the second league.
The continuation of creating chances down the right may be influential when it comes to European success.
What's next for Arsenal?
A win is important in terms of their league finish, but also equally important for confidence before the Gunners travel to the Czech Republic.
A true performance from Arsenal's front men is also crucial after a poor goal scoring display on Thursday night.