Crystal Palace have their second game in under a week as they host Thomas Tuchel's revitalised Chelsea side who took a big hit in their last game against West Brom.
The Eagles are unbeaten in their last three games at Selhurst Park, securing stalemates against Fulham and Manchester United before beating West Brom thanks to a Luka Milivojevic penalty.
The defence has been solid at home recently but they will face the likes of Timo Werner, Kai Havertz, Hakim Ziyech and in-form Mason Mount, who will want revenge after their 5-2 thrashing to relegation candidates West Brom.
Last time out, Chelsea bounced back from their awful showing at Stamford Bridge with a solid 2-0 win against reigning Portuguese champions, FC Porto, thanks to a clever Mount finish and a wonderful solo effort from full-back Ben Chilwell.
Roy Hodgson has a number of injury concerns going into the London derby with Chelsea. Nathaniel Clyne, Nathan Ferguson, James McArthur, James McCarthy and James Tomkins are all doubts.
Michy Batshuayi scored off the bench to equalise for Palace against Everton on Monday night, however, he won't be able to play against his parent club, as he is ineligible due to his loan agreement with the Eagles.
Thiago Silva is the only absentee for the Blues as the Brazilian serves a one-match ban for his red card against West Brom.
N'Golo Kante and Christian Pulisic were fit enough to play against Porto in Wednesday's 2-0 UEFA Champions League win, and Tuchel is expected to shuffle his squad around in order to prepare for the second leg.
Kurt Zouma, Marcos Alonso, Olivier Giroud, Ziyech and Callum Hudson-Odoi are all in with a chance of starting against the Eagles.
Crystal Palace possible XI: Vicente Guaita, Joel Ward, Cheikhou Kouyate, Gary Cahill, Patrick Van Aanholt, Jordan Ayew, Milivojevic, Jairo Riedewald, Eberechi Eze, Christian Benteke and Wilfried Zaha.
Chelsea possible XI: Edouard Mendy, Cesar Azpilicueta, Zouma, Antonio Rudiger, Hudson-Odoi, Mateo Kovacic, Kante, Alonso, Mount, Ziyech and Werner.
Palace have only won 12 times against Chelsea, whilst the Blues have emerged victorious on 30 occasions. Both London sides have had to settle for a point in 15 games.
Chelsea have won each of their last six Premier League games against the Eagles. They are also on a promising run of eights win in 10 away games against the same opposition.
Palace are unbeaten in their last two games and they will take inspiration from West Brom's thrashing over the Blues, as the Eagles aim to get their first home win over Chelsea since 14 October 2017.
Ones to Watch
Crystal Palace - Wilfried Zaha
On the ball, he is always threatening and provides an outlet for Palace, especially from the counter-attack.
The tricky winger can bring the ball forwards whilst having the quality to pick out a pass and get the ball back to produce an effort on goal or set up a chance.
Zaha must be watched at all times by Chelsea before he can be allowed to punish their backline.
Chelsea - Mason Mount
The England international is in-form and has bounced back superbly after a horrendous league encounter against the Baggies.
Wednesday night was huge for Chelsea and Mount delivered with a wonderfully taken goal against Porto which helped the Blues to a two-goal advantage before the second leg.
Mount has proved that he can show up in the big games and Palace can not afford to leave the academy graduate any space in their final third.
Chelsea 4-0 Crystal Palace (03/10/20)
Debutant Chilwell, opened his account for Chelsea shortly after signing from Leicester City.
Hudson-Odoi's cross was initially blocked but Mamadou Sakho's clearance went straight back to the winger who set up Azpilicueta, and his blocked effort deflected into the path of Chilwell who smashed home.
The floodgates opened, and Chilwell grabbed an assist when his corner was initially blocked before his second cross found the head of Zouma whose looping header was just beyond Guaita's reach.
The result was beyond doubt for Chelsea when Tyrick Mitchell brought down Tammy Abraham. This allowed Jorginho to convert his first penalty, before Havertz was brought down for a second penalty, and the Italian put away his second spot-kick.
Where to watch on TV
The game will be shown live via Sky Sports. Coverage starts from 5pm with kick-off scheduled for 5:30pm on Saturday, April 10, 2021.
The match will be behind closed doors at Selhurst Park due to ongoing COVID-19 regulations.
Palace have only suffered one defeat in their last six matches and have held Manchester United and Everton, but they have failed to score in three of their last four games.
Chelsea have bounced back after their 5-2 thrashing to the hands of West Brom, with a 2-0 first-leg win over Porto in the quarter-finals of the Champions League.
The Blues will be looking to get their top-four hopes back on track; especially with their god run of form under Tuchel's reign. Palace close the season with tough home games against Chelsea, Manchester City, Aston Villa and Arsenal, so it could be likely that the Eagles will not get many points at Selhurst Park.
Prediction: Crystal Palace 0-2 Chelsea