Sean Dyche's men head into this one on the back of a collapse against Southampton, a game in which Burnley led 2-0 before throwing away three cheap goals to The Saints and ultimately drop points.
Steve Bruce's side, on the other hand, managed to pick up a much needed point at home to Tottenham Hotspur, with Joelinton and Joe Willock scoring in a 2-2 draw.
Newcastle have the upper hand in the previous meetings between these sides, with Burnley only coming out victorious twice in the last nine games where these two have faced off.
In the reverse fixture, Bruce's men came out with the three points, as a Callum Wilson double and Allan Saint-Maximin goal was enough to see off an out-of-sorts Burnley side, in a 3-1 win.
Dyche's men will again be without joint-top all-time Premier League goalscorer for The Clarets, Ashley Barnes (thigh), whilst Republic of Ireland internationals Kevin Long (calf) and Robbie Brady (calf) also miss out after picking up injuries during the international break.
However, in a boost for the Lancashire side, defenders Phil Bardsley and Erik Pieters have both been passed fit for this weekend's game, with the latter being subbed off after half-an-hour in the previous game against Southampton
Charlie Taylor returned from injury in last week's game however, and will surely fight Pieters for that left-back slot.
The Magpies have been rocked by a potentially season ending foot injury for captain, Jamaal Lascelles.
Both Federico Fernandez and Ciaran Clark will battle for the spot to replace their injury-stricken skipper.
Bruce confirmed that the club were 'cautious' about the chances of the reverse fixtures matchwinners Callum Wilson (thigh) and Allan Saint-Maximin but that the two have trained all week.
Ryan Fraser (calf), however will definitely miss out, and Andy Carroll (muscle problem) is also expected to be absent for the visit to Turf Moor.
Long term absentees Isaac Hayden (knee) and Fabian Schar (knee) will also miss.
Ones to watch
Chris Wood is on course to become Burnley's all-time leading Premier League goalscorer and will hope to complete the feat in this Sunday's game.
Wood is the top-scorer in a season where The Clarets have lacked goals and has bagged three in the last three league games.
The New Zealand international will have to be on top form if Dyche's side are to come away with a much needed three points here.
For The Magpies, it is clear one man can get the Toon excited and that man is Saint-Maximin.
The Frenchman netted Newcastle's last goal away from home, against Manchester United, and Burnley's defence should expect a tough game facing the tricky winger.
Burnley: Pope, Lowton, Tarkowski, Mee, Taylor, Gudmundsson, Brownhill, Westwood, McNeil, Wood, Vydra
Newcastle: Dubravka, Krafth, Clark, Fernandez, Dummett, Ritchie, Almiron, Shelvey, S. Longstaff, Wilson, Saint-Maximin
Where to watch
The game is expected to kick off at 12:00pm GMT on Sunday, and can be viewed on both Sky Sports Main Event and Sky Sports Premier League.