Unlike their opponents, Stoke City have little to play for but pride as they sit in 12th spot - although they would no doubt love to finish in the top 10 and end the season well.
Their previous game saw some poor finishing as they drew 0-0 at home to Preston North End.
Coventry City are in 18th and are nine points from the drop, with two recent consecutive wins against Rotherham and Barnsley edging them to safety in their first season back in the Championship.
Points at the bet365 Stadium should see the Sky Blues secure their position, with just three games left to play afterwards.
The Potters have no new injury concerns, but remain without James McClean, Tyrese Campbell, Nathan Collins, Joe Allen and Tashan Oakley-Boothe, with none expected to play again this season.
Stoke will be without centre-back Harry Souttar, who has been a star performer for Michael O'Neill's side this season, after he was sent off in the dying embers against Preston.
Nick Powell has been declared fit for the game after picking up a knock in the Preston match off the back of a heavy challenge.
Coventry have been dealt a tough injury blow, with the news that versatile defender Josh Pask will not play again this season.
The 23 year-old suffered a fractured cheekbone against Bournemouth three games ago.
The game will come just too soon for Fankaty Dabo, with his lengthy injury layoff set to come to an end in the coming weeks.
Neither Ben Sheaf nor Jodi Jones will feature again this campaign.
Stoke City (4-3-3):
Davies; Smith, Batth, Chester, Norrington-Davies; Thompson, Mikel, Clucas; Brown, Powell, Norton.
Coventry City (3-4-1-2)
Wilson; Ostigard, McFadzean, Hyam; Da Costa, Kelly, James, McCallum; Hamer; Godden, Biamou.
Ones to watch
Nick Powell has been the Potters’ star man this season, imperative to every success they have had so far. With 12 goals and three assists to his name, the former Manchester United man is undoubtedly enjoying the best campaign of his career to date.
Stoke will want the 26-year-old to be fit and firing against a usually-leaky Coventry backline. Powell is currently the most fouled player in all four top divisions, showing just how much of a nuisance he can be to opposition defenders at times.
Hamer, 23, arrived at the Sky Blues in the summer from Dutch outfit PEC Zwolle, and has enjoyed a largely successful season given it is his first in English football.
Used at both right wing-back and central midfield, he chipped in with five goals and one assist and was Coventry's star man in the first half of the season, but his form has faltered in recent months. Mark Robins' side will hope he can find some of that star quality to push them over the line in the Potteries.
The reverse fixture earlier in the season saw a 0-0 draw at St Andrew's on Boxing Day.
Before that game, the last meeting between the two saw Coventry, then in League Two, best a then-Premier League Stoke team 2-1 in the FA Cup in 2018.
That game was the end of then-Stoke manager Mark Hughes, with his sacking announced later that day.
How to watch
The match kicks off at 19:00 BST on Wednesday April 21.
Match passes for iFollow coverage can be purchased from either club's website for £10 for customers in the UK and Ireland and £7 for viewers from elsewhere.
The game will also be televised on the Sky Sports Main Event Red Button.
What the managers have said
Stoke boss Michael O'Neill says he has warned his players, insisting that they will be ready for the opposition's threat. He said:
“Coventry have good energy and they are fighting for their lives.
“They have come up into the division and that leads to hungry players who want to play in the Championship for another year, and want to show they are good enough and are Championship class, and Coventry are a Championship club.
“I spent time there as a player, so I know that, and we have to be ready for the game.”
Coventry boss Mark Robins does not want his players to let up until they are mathematically safe from relegation. He said:
“We have had two really good results, but we have to focus on Wednesday and finish this job off.
“Ultimately, until it’s mathematically impossible, we have to keep going. We just have to keep grinding things out and if we can play off the back of it then brilliant."