The home side are in dreaded form, having lost four consecutive games and seeing their lofty play-off ambitions recently squandered, it's all about rebuilding for next season now with joint managers Mark Trueman and Conor Sellars.
This coincided with the Bantams on Saturday, as their early lead was quickly overturned and they fell to a defeat at the hands of Port Vale, with their first visit to Vale Park in four years.
Bowyer has had an impressive start to management with Salford, with just one loss in his previous seven outings and transforming the Ammies into a likely force to be involved in the play-offs come May.
However, Reece Staunton, Niall Canavan, Harry Pritchard and Zeli Ismail all remain long-term absentees and won't feature again this season.
Salford welcomed back Mani Dieseruvwe back to the bench on Saturday after an injury, so he'll be hoping to push Henderson for a start on the pitch.
Bruno Andrade and James Wilson will both be unavailable after picking up knocks, but should feature again before the end of the campaign.
Richie Towell picked up a straight red card against Mansfield on Saturday, and therefore will begin the first of his three game ban, meaning hos season could be over depending on the Ammies play-off stance.
Bradford City: Hornby; Sutton, A O'Connor, P O'Connor, Wood, Watt, Cooke, Vernam, Evans, Donaldson, Cook
Salford City: Hladky; Bernard, Eastham, Turnbull, Touray, Lowe, Threlkeld, Gotts, Coutts, Hunter, Henderson
Ones to watch
A huge shout for the Bantams player of the season, the former Leeds United prospect has flourished under Trueman and Sellars.
Forming a formidable partnership with either Canavan or Anthony O'Connor, Paudie has appeared confident and comfortable in the back-line, averaging a rating of 7.15 and proving a combative player, having already picked up 10 yellow cards in his role. Coming up against Henderson, Paudie will want to assert his dominance in that centre-back position.
Despite being 36-years old and coming towards the end of his career, Henderson is still one of League Two's most prolific frontmen.
The Rochdale legend has netted 16 goals this season, including absolute stunners against Forest Green Rovers and Mansfield at the weekend, but has also acted as the helper at times. Managing six assists this season and linking up with Hunter on several occasions, he remains a feared forward.
Bradford are yet to ever beat Salford in league action, having drawn once and lost twice to their counterparts. The most recent result was the most embarrassing one for the Bantams, as a brace from Luke Burgess and a strike from Henderson helped guide the Ammies to a 3-0 victory at the Peninsula Stadium.
How to watch
The match kicks off at 19:00 BST on Tuesday April 25.
Match passes for iFollow coverage can be purchased from either club's website for £10 for customers in the UK and Ireland and £7 for viewers from elsewhere.