Jannik Vestergaard was sent off after just ten minutes for Saints but James Ward-Prowse opened the scoring after an hour for the hosts from the spot, after a handball by Kelechi Iheanacho.
Jonny Evans scored his second goal in three games to level the scoring for the Foxes. Leicester were certainly wasteful, recording 23 shots on target, but they couldn't take the three points.
Brendan Rodgers spoke to LCFC TV after the game.
Thoughts on the game
Southampton defended like gladiators throughout, kudos to them. With only ten men, for 80 minutes of the game, to get a 1-1 draw is a great result.
It was certainly a different result to the last time Leicester visited the south coast. However, the Foxes do remain four unbeaten ahead of a very tough run-in.
Rodgers had his say: "You sometimes just need that little bit of luck, that bit of quality, but there’s no excuses. Southampton deserved a point, there’s no doubt about that, and we didn’t do quite enough to win."
He went on to reiterate their disappointment: " We're disappointed with the point, especially with the circumstances of the game, playing with 11 vs 10 for so long. Normally we're good in those situations."
The East Midlands side have played a tremendous amount of football this season and this game showed tiredness.
The Northern Irishman said: "I believe it will be an important point. We know we still need to win more games from the final four, so that will be our focus now."
"We'll go into next week against Newcastle, we'll recover from this game."
"It's been a tough schedule, this was the fourth game in 13 days, and I felt in that first 60 minutes, you could see that. We'll recover now, have a good week next week and then look to go again on Friday."