With Burton safe, they don't have much to play for, but it's a huge occasion for Oxford.
They just have to better Portsmouth's result to sneak in at the last spot.
The same goes for the Brewers, Jimmy Floyd Haselbaink has an array of players he can choose from, and in the last couple of matches he has been chopping and changing. After they secured their stay in the league, why not try something new going into the end of the season.
Ryan Broom could get his first start for Burton since February following his late equaliser against Gillingham last time out.
Oxford United - 4-3-3
Stevens; Ruffels, Atkinson, Moore, Long; Henry, Sykes, Rodriguez; Barker, Taylor, Lee.
Burton Albion - 4-2-3-1
Garratt; Hamer, Carter, Brayford, Earl; Taylor, Clare; Powell, Edwards, Rowe; Akins.
Ones to watch
Matty Taylor - Oxford United
What a season Matty Taylor has had for Oxford, being their top scorer, the the 31 year-old will be happy with the return. Taylor, born in Oxfordshire is now serving his third spell at the club.
He will cause trouble for the Brewers’ defence with his pace and nippy feet and will be hoping to fire the U's into the play-offs.
Ryan Broom - Burton Albion
Ryan Broom scored his second goal for Burton last time out in essentially the last kick of the game to equalise against Gillingham. He did the same just a few weeks back against Plymouth Argyle, proving he is the man you want to score when it's most needed.
The Welshman will be looking to start his first game in over two months for the side after impressing recently whilst coming off the bench.
When the sides met last time out on the turn of the year, it was Oxford who came out on top at The Pirelli. The U's were 5-1 winners, with Olamide Shodipo and Josh Ruffels getting a brace each after Taylor opened the scoring.
How to watch
Due to current restrictions in the UK, there will be no fans in attendance at The Pirelli. However, the game is available to watch on iFollow. This kick off is at 12:00 BST.