Whilst the Wanderers have nothing to play for in their final three games of the 2020/21 campaign, Spurs sit seventh and eight points away from the UEFA Champions League places.
Ahead of the game, VAVEL goes back in time and look at three classic meetings between the two sides.
Tottenham 2-3 Wolves, 1st March 2020
Wolves trailed twice in north London before Raul Jimenez's winner won the game for Nuno Espirito Santo's side 3-2.
Steven Bergwijn poked in the opener after Rui Patricio originally denied Dele Alli, but the now-Spurs defender Matt Doherty equalised when Diogo Jota's surging run and cross wasn't dealt with by Japhet Tanganga.
On the brink of half-time, scored his fifth goal for the club when his left-footed strike curled past Patricio and into the net.
Into the second half and after failing to keep his header down from an earlier free-kick, Jota pegged Spurs back when Doherty's low cross was tapped in by the forward.
Over 15 minutes later, Jimenez's smart winner secured the win and boosted their hopes of earning a Champions League spot.
Tottenham 1-3 Wolves, 29th December 2018
Newly promoted Wolves dealt a damaging blow to Tottenham's title hopes as they came from behind to defeat Mauricio Pochettino's side.
Harry Kane put Spurs into the lead with a spectacular 25-yard strike, but Wolves punished a tired Tottenham side with three goals in the final 18 minutes.
After missing a host of chances, Spurs were pegged back with a powerful header from Willy Boly before Jimenez's weak attempt beat Hugo Lloris.
Heldar Costa beat the offside trap before tucking the ball past the French keeper in the 87th minute to mark the fixture as one of the clubs most memorable fixtures since returning to the top flight.