Marcelo Bielsa's men sit 10th in the table with 50 points while the Clarets are 15th, only having seen their top-flight status preserved this past week.
Nick Pope is suffering from a shoulder injury that caused him to miss two games last month and with the Clarets' survival ensured, manager Sean Dyche may play it cautiously and rest the England international.
Dale Stephens is doubtful with an ankle injury while Phil Bardsley will miss out due to a hernia while Dyche confirmed Robbie Brady and Kevin Long will miss the remainder of the season.
Leeds captain Liam Cooper hopes to return to the starting lineup after missing the last four games through suspension and a glute injury.
Kalvin Phillips (knee), Raphinha (thigh) and Rodrigo (muscle strain) are all fit and pushing for places in the starting XI. Forward Helder Costa remains sidelined.
Burnley: Pope; Lowton, Tarkowski, Mee, Taylor; Brownhill, Cork, Westwood, McNeil; Wood, Vydra
Leeds United: Meslier; Alioski, Struijk, Llorente, Ayling; Phillips; Harrison, Roberts, Dallas, Raphinha; Bamford
Ones to watch
Ex-Leeds man Chris Wood has led the Burnley attack, scoring 12 goals this season, including five in his last three matches. He netted a hat-trick against Wolverhampton Wanderers earlier in the season.
Patrick Bamford picked up his 15th goal of the season last time out in Leeds' 3-1 victory against Tottenham Hotspur and has been among the best strikers in his first season in the top flight.
On December 27th, 2020, the two sides met for the first time in the Premier League with Leeds emerging as 1-0 winners at Elland Road.
Bamford converted a eight-minute penalty for the only goal of the match, although Ashley Barnes had the equalizer ruled out after it was determined Ben Mee had fouled Ilian Meslier.
How to watch
The match will be shown on BT Sport with Leeds subscribers able to watch through LUTV while Burnley will offer the game on Clarets +. Kick-off is at 12:30pm.