Ironically, the last game of the season will be the first to host fans of any capacity since United’s 2-0 victory over Manchester City in March 2020, in what promises to be a tense affair following recent public demonstrations of fan unrest.
With the season coming to an end, here’s a look back at some of the weird and wonderful last games that have taken place at Old Trafford over the years.
Manchester United 2-0 Crystal palace (2016/17)
With a Europa League final on the horizon, and top four now out of reach, this nothing more than a dead rubber for United.
This was shown in the starting lineups, with youngsters Joel Pereira, Timothy Fosu-Mensah, Demetri Mitchell, Axel Tuanzebe, Scott McTominay and Josh Harrop all starting for the reds.
With the opportunity of a lifetime handed to the youngsters, it was Josh Harrop who stood up and made the most of it.
Just 15 minutes into the game, Harrop latched onto a through ball from Paul Pogba down the left, carrying it into the box before calmly cutting inside the Crystal Palace full back.
Then, with composure past his years, Harrop curled an effort into the far corner to give United the lead on what turned out to be his only appearance for United.
The game finished 2-0 to United after a marvellous Paul Pogba display, giving them some crucial momentum heading into their European final.
Manchester United 3-1 Hull City (2013/14)
The surprise selection of the game came as youngster James Wilson, now of Salford City, lead the line for United in front of a packed Old Trafford for his full debut.
Academy graduate Wilson took his opportunity with both hands, scoring two of United’s three goals on the day, before being substituted to a magnificent reception from the home crowd.
Later on in the match, player-manager Giggs substituted himself on in place of Tom Lawrence to make what would turn out to be his last ever appearance at Old Trafford.
A historic day all round.
Manchester United 2-1 Swansea City (2012/13)
Having already secured their 20th league title a few weeks prior, all the focus of United’s final home game of the season switched to the departing Sir Alex Ferguson.
With the news that his 26-year long reign at the club was coming to an end, Ferguson was given a guard of honour from both sets of players prior to kick off.
With a resilient Swansea looked likely to secure a 1-1 draw after a heroic defensive display, but it was one of ‘Fergie’s’ longest-serving players, Rio Ferdinand, who slammed home a last-minute volley to ensure the legendary manager left on the best possible terms.
A fitting end to a true legend of the club.