With not much changing since the first leg, we could see both sides unchanged.
However, Blackpool boss Neil Critchley will be hopeful that Luke Garbutt will shake off a minor back injury sustained just three days ago. Critchley might be reluctant to take any risks, knowing they are potentially only 90 minutes away from a Wembley play-off final.
Meanwhile for the visitors, Olamide Shodipe could be a player thats brought into the starting XI to combat the strong Blackpool defence. Karl Robinson's side missed Shodipe's physicality from the start in the first-leg.
Maxwel; Turton, Ballard, Husband, Lawrence-Gabriel; Embleton, Stewart, Dougall; Yates, Simms, Anderson.
Oxford United: 4-3-3
Stevens; Hanson, Moore, Atkinson, Ruffels; Henry, Brannagan, Skyes; Lee, Taylor, Shodipe.
Ones to watch
Ellis Sims - Blackpool
Sims was the superstar of the first-leg, scoring two crucial goals. The 20-year-old, on loan from Everton has had a fruitful spell in a tangerine shirt - albeit a short one.
The striker has scored ten goals since joining the Seasiders. Critchley will surely be doing everything he can to get Sims to return next season, especially if the club are in the second tier.
His pace and power is likely to cause the U's some more trouble - especially with fans back at Bloomfield Road.
Olamide Shodipo - Oxford United
After ending the season very well at home to Burton Albion, Shodipo was a huge factor as to how Oxford snuck into the play-offs. The Irishman would have been disappointed not to start in the first leg.
The U's missed his strong build, and his partnership with top scorer Matty Taylor. If he does on the night, he could have a big impact. If Blackpool score three away, why can't Oxford.
Blackpool were victorious in the first leg, winning 3-0, you can watch the highlights below.
The last time they played before that was in March, again the Tangerines were victorious away - winning 2-0.
How to watch
There will be some fans in attendance at Bloomfield Road with the latest restrictions eased in the UK. However, for those that aren't lucky enough to get tickets, the game is on Sky Sports. Kick-off is at 19:45 BST.