The Clarets finished one place above the drop zone, in 17th, last time out, but will look to improve on that following a positive pre-season, winning six out of their seven friendlies.
Graham Potter's Seagulls were classed as an unlucky team last season, with their expected goals (xG) being up there with the highest in the league, despite a 16th place finish.
The hosts don't have a great record in this fixture, as they haven't beaten the South-Coast side in the past four meetings.
New Zealand Olympic hero Chris Wood, is also expected to feature, despite only returning to the squad 10 days ago, after a quarter-final run for the Kiwi's.
Both will miss this game.
Ones to watch
Chris Wood is one of Sean Dyche's key men heading into this season, and after 12 goals last season, will look to hit the ground running once more.
Wood also has a decent record in this fixture, scoring three times in the last five meetings between these sides.
Yves Bissoumais a key cog to the Brighton system and when he is ticking, the team seem to perform well.
Top performances last season earned him multiple plaudits, and links to Arsenal this summer come with reason.
If the Mali international is on form, then the Clarets midfield will be in for a tough afternoon.
Burnley: Pope, Lowton, Tarkowski, Mee, Taylor, Gudmundsson, Brownhill, Westwood, McNeil, Vydra, Wood.
Brighton: Sanchez, Webster, Dunk, Veltman, March, Bissouma, Mwepu, Gross, Trossard, Mac Allister, Maupay.
Where to watch
The game is expected to kick off at 3:00pm GMT on Saturday, with highlights being available on the Sky Sports YouTube channel, following the game.