The Robins have taken four points from their opening four fixtures and are coming off of a 3-2 defeat at the hands of Fleetwood Town in their last league match. They saw off Gillingham on penalties in the second round of the Carabao Cup on Tuesday.
Burton will hope to have midfielder Bryn Morris in the side for the first time this season as the midfielder suffered from a dead leg in pre-season and experienced complications in his recovery.
Ciaran Gilligan and Kane Hemmings are back training with the first-team, but are unlikely to feature here as the game has come too soon for both of them. Tom O'Connor is also out after suffering a hamstring injury in the defeat to Cambridge.
Michael Bostwick and Terry Taylor are in self-isolation and following COVID-19 guidelines and protocols.
Cheltenham do not have any players listed as out, but manager Michael Duff could be looking at several changes to his side with this being their third match in the last eight days.
Burton Albion: Garratt; Brayford, Shaughnessy, Leak, Hamer; Mancienne, O'Connor; Smith, Powell, Akins; Patrick
Cheltenham Town: Evans; Raglan, Boyle, Tozer; Hussey, Wright, Thomas, Sercombe, Long; Vassell, Williams
Ones to watch
Callum Wright is in his second spell with Cheltenham after returning to the Robins from FA Cup champions Leicester City and has already contributed two goals and an assist while forward Alfie May has found the back of the net three times.
Burton have made a strong start to the season in part because of the outstanding play of goalkeeper Ben Garratt. The 27-year-old has already kept two clean sheets in victories over Shrewsbury Town and Sunderland.
This is the first meeting between the two sides as members of League One. Their previous 12 meetings have been in EFL League Two and they haven't played since 2015.
The Brewers have won the last three matches against the Robins with their most recent meeting a 3-1 victory at Whaddon Road on goals by Stuart Beavon, Adam McGuirk and Phil Edwards.
Wes Burns grabbed a consolation goal for Cheltenham, who haven't beaten Burton since November 2012 and haven't tasted victory at the Pirelli Stadium since October 2011.
How to watch
The match will be shown on Sky Sports Football. Coverage begins at 19:30 BST with kick-off at 19:45 BST.