The Baggies are unbeaten in their opening six league games, winning four and drawing two. They drew 1-1 at home to Millwall on Saturday and are one point above second-placed Fulham and third-placed Stoke City, both of whom play on Wednesday.
Derby enter the game sitting 16th and are looking for their second league win of the campaign. They lost 2-0 at Birmingham on Friday night - stretching their winless run to four matches in all competitions.
Wayne Rooney's men have six points so far but could still receive a nine-point deduction with another three suspended due to financial breaches.
The Rams will be missing Festy Ebsosele due to a hamstring injury, but he should return to training this week. Long-term absentees Colin Kazim-Richards (Achilles) and Krystian Bielik (knee) also remain sidelined.
Craig Forsyth remains suspended for the next two games after receiving a retrospective three-match ban for a challenge in the draw against rivals Nottingham Forest.
Kamil Jozwiak is available after missing Friday's game following international commitments, while Jason Knight will be hoping for a start, having made his first appearance of the season off the bench at St Andrew's.
West Bromwich Albion
Johnstone; Ajayi, Bartley, Kipre; Furlong, Livermore, Mowatt, Townsend; Phillips, Robinson, Diangana.
Roos; Byrne, Jagielka, Davies, Buchanan; Bird, Shinnie; Jozwiak, Morrison, Lawrence; Baldock.
Ones to watch
Alex Mowatt is the Baggies' one to watch. The 26-year-old played under Ismael at Barnsley last season and was instrumental in helping them reach the play-offs, scoring eight and assisting seven. He penned a three-year deal with West Brom in the summer after his contract with the Tykes expired. The Doncaster-born midfielder has two goals and one assist so far this season.
It's tough to choose a standout performer for Derby this season, but captain Tom Lawrence is capable of causing the opposition problems. The 27-year-old scored a brilliant goal while playing the false-nine role against Forest to put the Rams ahead. He must now start producing on a more regular basis.
The most recent meeting between the sides was in the 2019-20 Championship season. West Brom won 2-0 at home on that occasion with goals from Grady Diangana and O'Shea before Derby's Louie Sibley was sent off in stoppage-time.
The Rams' last away victory in this fixture came in 2018 when they won 4-1 under Frank Lampard.
Overall they have met 121 times, with Derby winning 53 while the Baggies have won 38.
Back in 2020:
How to watch