The Pilgrims haven't lost in League One since their opening day defeat at Rotherham United, winning four and drawing two of their six games since. They won 1-0 at AFC Wimbledon on Saturday and currently sit fourth, knowing victory would send them above leaders Wigan Athletic but having played a game more.
Pompey won their opening three league games but have not tasted victory since. They are on a winless run of five matches in all competitions and have lost their last three in League One, including Saturday's 2-1 home defeat to Cambridge United. Danny Cowley's men sit 15th on 10 points but could climb into the top six with a win.
Portsmouth will be without captain Clark Robertson (hip) and Connor Ogilvie (quad).
Joe Morrell could return to the starting eleven after only making the bench on Saturday because of a family bereavement.
Skipper Joe Edwards and Danny Mayor could be available as they both recover from a thigh injury.
Portsmouth: Bazunu; Freeman, Downing, Raggett, Brown; Morrell, Williams; Harness, Tunnicliffe, Curtis; Marquis.
Plymouth Argyle: Cooper; Wilson, Scarr, Galloway; Garrick, Camara, Houghton, Broom, Grant; Jephcott, Hardie.
Ones to watch
Midfielder Ryan Tunnicliffe is the player to watch for Pompey. The 28-year-old, who started his career at Manchester United, joined the club on a two-year deal in the summer after his contract with Luton Town expired. Portsmouth fought off interest from Championship clubs for his signature, and he has scored one goal while providing three assists so far.
Striker Ryan Hardie is Plymouth's one to watch. The former Rangers man had two loan spells at Home Park before joining permanently from Blackpool in January. He's scored six goals and provided one assist in all competitions, including a brace against Championship outfit Peterborough United in the EFL Cup.
Both games between the sides ended 2-2 last season to make it three draws from the previous three meetings.
Plymouth haven't won away from home in this fixture since 2016, with three draws and two defeats in their last five visits.
They met in the 2016 League Two play-off semi-finals, and the Pilgrims advanced 3-2 on aggregate before losing 2-0 in the final against AFC Wimbledon.
Most recent meeting:
How to watch