The Seagulls have picked up 13 points from their opening six matches, while the Gunners have won three in a row following a three-match winless run to begin 2021/22.
Yves Bissouma is facing a late fitness test on his knee injury and Brighton will re-evaluate his status for Saturday's match closer to kick-off.
The Malian midfielder has impressed as the engine in the middle during Brighton's excellent start to the season; his presence was missed at the club's previous match.
Brighton & Hove Albion: Sanchez; Veltman, Dunk, Duffy, Cucurella; Groß, Bissouma, Lallana; Trossard; Maupay, Connolly
Arsenal: Ramsdale; Tierney, Magalhães, White, Tomiyasu; Lokonga, Partey; Smith-Rowe, Ødegaard, Saka; Aubameyang
Ones to watch
The Frenchman has scored in four of Brighton's six league matches this season and his stoppage-time equalizer in the M23 Derby against Crystal Palace earned the Seagulls a point. His pace to get behind defenders and goal-scoring prowess will make him a handful for the Arsenal defense.
The 21-year old signed a new contract with Arsenal and he turned in a superb performance in the victory over Tottenham, scoring once and setting up another as the Gunners ran out 3-1 winners. His vision, work rate and understanding of the game are his strongest assets.
Arsenal did the double over Brighton last season without allowing a goal, winning 1-0 at the AMEX and 2-0 at the Emirates Stadium.
There will be television coverage of the match as Sky Sports Premier League will bring you all of the action with kick-off set for 17:30.