The Italian, who was appointed just this week as Spurs manager, opted to bring the strongest side possible in Tottenham's match against Eredivisie's side, Vitesse.
The 'Lilywhites' fell to Vitesse earlier in the group stage, therefore they were looking for revenge to try and make a run to win the Group G of the competition.
Tottenham would end up defeating the 'Vites' by 3-2.
Story of the game
Son and Lucas scored early in the first half, right before an own goal by Vitesse's defender, Jacob Rasmussen gave a three goal cushion to the home side.
Tottenham Hotspur (@SpursOfficial) November 4, 2021
Just when things were looking really good for Spurs, Vitesse fought back and managed to get two goals back before the first half of play finished.
Rasmussen made ammends for his own goal by scoring Vitesse's first, while Matus Bero recorded his first goal of the European campaign just a few minutes after.
The second half was more of the same intensity and although both teams failed to score, there was plenty of action, including three red cards.
First, Romero was sent off with a double yellow, leaving Tottenham down to 10 men with a little bit over half an hour to be played in the game.
Despite dominating the next 15 minutes of the game in terms of possession and shots in target, Vitesse would proceed to have two men sent off in the span of four minutes, one of them being their goalkeeper for an illegal hand outside the box.
The Italian manager, Antonio Conte addressed the media following Tottenham's 3-2 win over Vitesse.
"My first impression, a crazy game. We were winning 3-0 and dominating the game, created many chances to score," Conte said. "I decided to change and make three changes as we lost the balance. In the end I think we deserved to win.
My players showed me great commitment and great resilience. I think this team also needed to win suffering."