Chelsea built on their victory last weekend by managing to beat Juventus by four goals to nil at Stamford Bridge on Tuesday in order to ensure that they qualify for the round of 16 of the champions league, it means Chelsea will go into the match on Sunday with their confidence high.
Meanwhile, it's been a dramatic week for United. Following a humiliating four goal to one defeat against Watford last weekend, the United hierarchy decided to sack Ole Gunnar Solskjaer and leave Michael Carrick in temporary charge until they find an interim manager which looks very likely to be Ralf Rangnick.
United bounced back from their ignominious defeat against Watford by beating Villarreal CF by two goals to nil to secure their place in the Round of 16, it means United will go into the match on Sunday with a bit more confidence.
Carrick has got a fairly big list of unavailable players, Paul Pogba and defender Raphael Varane are not going to feature while Mason Greenwood, Edison Cavani, and Luke Shaw are all doubtful for various reasons. In addition captain Harry Maguire is also set to miss out following his red card last week against Watford.
Meanwhile, Thomas Tuchel has also got injuries to several key players. Left wing-back Ben Chilwell is set to miss out having picked up an injury during Chelsea's match with Juventus on Tuesday. Ngolo Kante was also injured while Matteo Kovacic looks set to miss out as he recovers from a hamstring injury. However, Kai Havertz should be available again after missing the match against Juventus.
Players to watch
With several attackers such as Romelu Lukaku and Timo Werner absent for the last few league games Chelsea have had to find an alternate way to score goals fortunately Reece James has stepped up to the mark.
James has scored three goals in his last three league matches to help propel Chelsea to the top of the table as well as getting on the scoresheet on Tuesday to help Chelsea beat Juventus by four goals to nil.
United have had a dismal season domestically so far that finds them sitting in a disappointing eighth-place 12 points behind Chelsea in first. However, it could be a lot worse if it wasn't for Cristiano Ronaldo.
Chelsea will know they will have to be at their best because even a tiny error and Ronaldo will more than likely score.
Last time out
The last time these two faced each other was last February where they played out a nil-all draw.
Both teams started the match very cautiously not wanting to give anything away, then in the 12th minute, Bruno Fernades had his shot blocked by a Chelsea defender.
Both sides continued to create chances as the match approached the 30-minute mark. However neither side could take any of them. United did have a chance to score just before halftime but Greenwood's shot from outside the box was blocked.
Chelsea started the second half much better and created an early chance when in the 49th minute Hakim Ziyech had his shot from the center of the box saved brilliantly by David De Gea.
United created their first chance of the second half in the 61st minute when Scott Mctominay received the ball in the Chelsea penalty box, However his shot towards the bottom right-hand corner was brilliantly saved by Edouard Mendy.
Both teams had a chance to win the match right at the death. Chelsea had a chance first, Kovacic received the ball on the edge of the United penalty area and bent a shot towards the bottom right-hand corner but De Gea saved it.
Then at the other end, Fred received the ball from Fernandes on the edge of Chelsea's penalty box and managed to get a shot away. However, he mishit the ball and it went straight down the middle of the goal making it easy for Mendy to gather the ball.
How to watch
Fans in the UK will be able to tune in to Sky Sports at 4 pm on Sunday with the match kicking off at 4:30 pm.