Antonio Conte's men arrive after a 5-0 demolition job against Everton on Monday night. Meanwhile, Ralf Rangnick's side will look for redemption after being humbled against Premier League leaders Manchester City on Sunday afternoon.
Both sides have struggled for consistency lately with both picking up 9 points from a possible 18 in their 6 most recent league games. With both sides desperate for a win, it should be an entertaining game at Old Trafford.
The Italian had news on Ryan Sessegnon saying:
"Bad news about Ryan Sessegnon. He had a scan and a muscular problem. Maybe we'll see him after the international break."
"Yeah we're talking about not a new problem. We have to with the medical department find a solution. Sometimes though there is a predisposition to have this type of problem."
The bad news continued for Spurs fans from Conte:
"About Skipp and Tanganga, they are not ready. We have to wait. In this moment, if you ask me a forecast about his (Skipp) return, I don't have an answer. For this reason I am really worried, we are talking about a player who was playing very well and we need another midfielder."
"Luke Shaw will miss out. Until yesterday, still testing positive for Covid. Scotty is a question mark, problems with his calf. Right now it's more likely he will not be available because if we risk him tomorrow he might be out for the game on Tuesday (against Atletico Madrid). I tend to be careful if it's a muscular injury."
Later on, Rangnick had positive news regarding Cristiano Ronaldo's condition:
"He resumed for training yesterday. He trained the whole training session and I expect him to train today. I would've thought he was available tomorrow. I haven't asked him if he's happy at Manchester at this club. He's fit again, resumed training yesterday and we shall see which formation we will line up with tomorrow."
"I'm okay, I'm training, I feel better and I'm ready to help the team."
De Gea; Dalot, Varane, Maguire, Telles, Fred, Mctominay, Sancho, Elanga, Fernandes, Ronaldo
Lloris; Doherty, Romero, Dier, Davies, Reguilon, Hojbjerg, Bentancur, Kulusevski, Son, Kane
In their previous 25 encounters, United have won 13 whilst Spurs have won 7. However, the last time the North London side travelled to Old Trafford, the demolished them 6-1 in a scintillating performance.
The past 5 meetings between Manchester United and Tottenham:
Tottenham 0 - 3 Man United (30th October 2021)
Tottenham 1 - 3 Man United (11th April 2021)
Man United 1 - 6 Tottenham (4th October 2020)
Tottenham 1 - 1 Man United (19th June 2020)
Man United 2 - 1 Tottenham (4th December 2019)
One to Watch
A week after scoring against his former side in the Manchester derby, the Englishman will be keen to take this momentum forwards in another massive game for United.
Despite only having 3 goals and 2 assists within 23 Premier League games this season, the 21 year-old has grown in confidence in recent weeks, making him a key player for Ralf Rangnick. The battle between him and Matt Doherty could prove pivotal in deciding the match.
Harry Kane will be the main threat to the Manchester United defence on Saturday evening, however 'Deki' should not go unnoticed. With 2 goals and 3 assists in 6 Premier League games, the Swedish international has hit the ground running since arriving on deadline from Juventus.
The 21 year-old has grown in confidence each week and seems to be a real threat to every defence he has faced. The trio of Heung-Min Son, Kane and Kulusevski could cause trouble to a struggling backline in Manchester.
Where to watch
The game is being broadcasted on Sky Sports Main Event on Saturday evening. Coverage begins at 5pm, with the game kicking off at 5:30pm.