Defoe is the joint 8th highest league goal-scorer for Tottenham with 91 goals across the two permanent and one loan spell at spurs making over 300 appearances for the club.
Several former teammates of Defoe's have paid tribute to the 39 year-old's career.
Dimitar Berbatov wrote: "What a player, good luck in the next chapter of your life, my friend" under the official announcement by Defoe earlier today.
Former tough tackling midfielder, Sandro, echoed Berbatov's congratulations, saying: "I feel very happy and proud to have played by your side."
One of Defoe's most successful former teammates, Luka Modric also paid tribute, calling the ex-England international a "legend"
Peter Crouch,, who formed a memorable 'little and large' partnership with Defoe also weighed in, tweeting: "Pleasure to have played with you! One of the best finishers we have ever seen."
Current Tottenham talisman, Harry Kane also joined the plaudits, thanking Defoe for giving him the number 18 shirt, saying: "Top striker, top bloke and someone who gave me some great advice early in my career."