Starting goalkeeper Alex McCarthy remains out with a hamstring injury while Lyanco remains a long-term absentee as he continues to nurse a thigh injury.
Leeds United: Meslier; Dallas, Struijk, Llorente, Ayling; Forshaw, Phillips; Harrison, Rodrigo, Raphinha; James
Southampton: Forster; Walker-Peters, Salisu, Bednarek, Livramento; Elyounoussi, Romeu, Ward-Prowse, Armstrong
Ones to watch
Luke Ayling (Leeds United)
Will be a key man in defense as he has been since joining the club in 2016. Scored the match-winner against Wolves in the Whites' last fixture.
Armando Broja (Southampton)
Is the Saints' leading scorer with nine goals and has put in the hard work recently that has translated into success. Scored the only goal of the match in the reverse fixture.
Southampton won 1-0 at St. Mary's in October thanks to, as mentioned above, a goal from Broja on his first start for the club.
Leeds were without six senior players for this match and they could only manage two shots in the whole of the match.
Saints scored the eventual winner in the 53rd minute at the end of a counter-attack. Nathan Redmond set up Broja, who fired high into the net.
The match will not be televised in the United Kingdom. Coverage is on LUTV for Leeds supporters and www.southamptonfc.com for Southampton supporters.
Kick-off is set for 3pm UK time.