Tuesday's hosts lost 6-0 at a Kidderminster Harriers side, who had only previously won one in their last nine games, on Saturday. The Sandgrounders' play-off push has halted recently, having not won in seven.
The Brakes fell to their fourth 1-0 defeat in a row in the league as Spennymoor Town came away victors. The Warwickshire outfit haven't scored in four, and the last time they put more than one into the opposition net was back in February.
Both teams are coming through injury crises, and are part-time sides impacted by the National League's decision not to change the registration deadline despite there being a later finish date to the season - a choice that has definitely given full-time clubs with bigger squads an advantage.
The Port could be without Jack Doyle, Charlie Munro, Connor Woods, George Newell and Declan Evans with their club website suggesting that those players are "nursing bumps and bruises".
Dan Turner returned to the Leamington squad on Saturday after an injury kept him sidelined, which meant they didn't have to play Junior English - a defender by trade - up top as the versatile 36 year old did against Darlington.
Kelsey Mooney is a long-term absentee for the Brakes, and several other players are playing through small injuries which may lead to players such as Josh Beeson and Jack Sang who have featured in the u23 side who have all but won the Midland League Reserve Division - tier 13 of the pyramid - being called up. Both have been on trial at Championship clubs recently.
With games on Friday as well, both sides will probably look to rest a few players who have played a lot recently.
Southport: Mason, Tharme, C Doyle, Anson, Oliver, Hmami, Walton, Bainbridge, Vassallo, Watson, Archer
Leamington: Hawkins, Meredith, Bushaj, Gittings, Mace, Lane, Williams, Walker, Taylor, English, Kelly-Evans
Ones to watch
Leamington did show attacking intent on Saturday, testing the Spennymoor goalkeeper on occasions and if they are to keep that up then Cam Mason will need to be on his game. The former Chesterfield and Curzon Ashton custodian is the Sandgrounders' number 1.
A strong defence has meant Leamington's scoring problems have luckily not impacted too much this season. The Brakes boast the best defence outside the top five and their mainstay centre back Jack Lane has started every single league game this season for Leamington, his height, defensive attributes and composure leading to the 'goals against' column not looking bad for them.
Marcus Carver's goal cancelled out Devon Kelly-Evans' ninth minute opener to share the points at Your Co-op Community Stadium earlier in the season.
Catch the highlights of that game courtesy of Leamington FCTV below.
How to watch
There is no video coverage of this National League North clash. Live text updates will be available on both clubs' twitter accounts. There will also be no commentary available.
Kick off at Haig Avenue is 19:45 BST.