It is Manchester City's first league game since defeating Burnley at Turf Moor a fortnight ago, and they will be hoping to bounce back to winning ways, having been knocked out of the FA Cup by title rivals Liverpool on Saturday.
Manchester City are likely to be without Kyle Walker for a second successive game, after the England international was spotted wearing a protective boot at Wembley following injury in Wednesday night's UEFA Champions League clash with Atletico Madrid.
Pep Guardiola is likely to recall Kevin De Bruyne to the team, with the Belgian left on the bench on Saturday after picking up a knock in Madrid.
Ruben Dias could return to the side for the first team in over two months, last years Premier League POTY has been out of action since sustaining a hamstring injury in the FA Cup win over Peterborough at the beginning of March.
Brighton & Hove Albion
Brighton will be sweating on the fitness of fullback Tariq Lamptey, after the England youngster was brought off in Saturday's win over Spurs with an apparent injury.
Jakub Moder and Shane Duffy will remain on the sidelines with long term injury problems, where they will be joined by influential holding midfielder Yves Bissouma, after the Malian was handed a two-match ban after picking up a 10th yellow card of the season in the 1-0 win at the Tottenham Hotspur Stadium.
Manchester City: Ederson; Cancelo, Stones, Laporte, Zinchenko; Rodri, Gundogan, Silva; Mahrez, De Bruyne, Foden
Brighton: Sanchez; Veltman, Dunk, Cucurella; Lamptey, Caicedo, Lallana, Gross, Trossard; Mwepu; Mac Allister
Ones to Watch
Manchester City's Riyad Mahrez is enjoying one of the most successful seasons of his career so far, the Algerian has found the back of the net 10 times in the Premier League this season, notching four assists.
Mahrez was rested in the FA Cup, although he did make a late cameo, setting up Bernardo Silva late in the tie to give the Citizens a glimmer of hope for a late comeback.
We expect to see him back in the starting lineup on Wednesday.
Brighton's Leandro Trossard will be looking to create a little slice of club history when he takes to the Etihad on Wednesday evening.
The Belgian could become the first player in the history of the club to score in three successive Premier League away games if he finds the back of the net in East Manchester, and having scored a late winner in North London on Saturday, confidence will be high for Trossard & co.
How to Watch
However as always, we will keep you posted with all of the pre and post match coverage right here on VAVEL. Be sure to head back after the full-time whistle to find out everything you need to know.