A win will guarantee the Blades a play-off finish this weekend as they look to gain promotion back to the Premier League at the first attempt.
Fulham won the league on Monday night after demolishing Luton Town 7-0 but they will be looking to end their impressive season on a good note as they travel to Yorkshire.
The Blades will be without talismanic striker Billy Sharp going into the last game of the season, but there is hope he will be fit for the play-offs if they do get there.
George Baldock returned to training this week and is expected to make the matchday squad this weekend.
Other than that the Blades have no new injury concerns going into arguably their biggest game of the season so far.
Fulham go into this game with a fully fit squad to finish their league title winning season in Yorkshire.
Sheffield United: Foderingham, Basham, Egan, Robinson, Osborn, Norwood, Fleck, Stevens, Berge, Gibbs-White, Ndiaye
Fulham: Rodak, Tete, Adarabioyo, Ream, Robinson, Reed, Cairney, Wilson, Carvalho, De Cordova-Reid, Mitrovic
They have only lost one game in their last six games helping them consolidate themselves as favourites for the last two play-off positions.
Fulham have been uncharacteristically inconsistent of late with two wins in their last six games.
Fulham will be looking to keep another clean sheet which would mean they would have went the whole season only conceding 19 goals away from home.
Ones to watch
Iliman Ndiaye is the one to watch in the Blades’ play-off hopeful squad this weekend as he looks to score in three consecutive matches to end the season.
The 22-year-old hasn’t had the most impressive first season in senior football scoring only six goals in 29 Championship matches, but one of them came in the reverse fixture of this game back in December.
But the Frenchman has been in fine form of late with three goals in his last four games as he has took over the scoring responsibilities with top scorer Billy Sharp out injured.
One man to keep an eye on in the Fulham side will be Fabio Carvalho as he plays his last game for Fulham before he makes a summer move to Liverpool.
The 19-year-old will be looking to add two more goal contributions to his tally to take him to 20 goals and assists for the season.
The Portuguese has over exceeded many people’s expectations in his first full campaign in senior football and will be looking to end his impressive season on a high as he moves to Jurgen Klopp’s quadruple hopeful Reds.
In the reverse fixture the Blades came out on top with a narrow 1-0 away win against the Cottagers thanks to a third minute wonder goal from Iliman Ndiaye.
In terms of the overall head to head between the teams the Blades once again come out in top with 31 wins in the 70 meetings compared to Fulham’s 23 wins.
The other 16 meetings ended in a draw but the Blades will be looking for all three points this weekend to have the playoff positions in their own hands come Saturday afternoon.
Where to watch on TV
This game isn’t being broadcast live on TV but foreign fans of both sides can watch the game using their club’s iFollow service.