The Potters have been in improved form as of late, but will be ultimately disappointed at how their season has petered out after being firmly in the race for promotion at the turn of the year.
Michael O'Neill's side have won three of their last five games, but lost 3-1 to Middlesbrough last time out.
They sit 13th in the table and can finish anywhere between 10th and 16th on the final day.
Coventry City have suffered a similar fate to their opponents this season, after chasing the play-offs all campaign only to fall away in the final few weeks due to some bad form.
Mark Robins' Sky Blues have won just two of their last nine matches, with a 2-1 loss to Huddersfield last week adding to their woes.
They are 11th in the table and are able to finish between 9th and 16th dependent on results.
Youngster Tom Sparrow is expected to be handed a debut, with D'Margio Wright-Phillips also likely to play a part after being out of the side in recent weeks.
Striker Matty Godden is set to make a return to the matchday squad after missing the last six games with a calf strain.
Liam Kelly may come back into the side after testing positive for COVID-19 last week.
Stoke City (3-5-2)
Bursik; Jagielka, Harwood-Bellis, Forrester; Smith, Allen, Baker, Powell, Tymon, Wright-Phillips, Brown.
Coventry City (3-4-1-2)
Wilson; Rose, McFadzean, Hyam; Eccles, Hamer, Allen, Maatsen; O'Hare; Gyokeres, Tavares.
Ones to watch
Powell is a product of the Crewe Alexandra youth academy and joined Manchester United at just 18 years old, but failed to ever nail down a spot for the Red Devils as a youngster. A fruitful three year spell at Wigan Athletic saw him join the Potters in 2019, where he scored 17 goals in 72 games in his first two seasons.
This time around the attacking midfielder began the campaign in red-hot form, but has played only in cameos since a fibula injury in October and a recurring hamstring problem since returning in January. He has seven goals in 20 appearances this season when he has been fit.
24-year-old O'Hare is finishing his third season as a Coventry player, and has shown steadied improvement since his arrival, initially on loan, from Aston Villa in 2019.
He helped the Sky Blues to the League One title in his first season and was subsequently signed permanently following his release by Villa. He has scored five and assisted eight goals this season, and been one of Mark Robins' most important players as they hunted a top-six finish for so long.
The reverse fixture saw the Sky Blues win 1-0 courtesy of a Viktor Gyokeres strike.
Stoke have lost their last two league games in this fixture, last losing three in a row against Coventry between 1985 and 2002.
Coventry have won seven and lost just three of their last ten away games against Stoke.
How to watch
The game kicks off at 12:30 BST on Saturday May 7.
It is not available to watch in the UK but overseas supporters can purchase a live stream of the game via either club website.