The Hatters were gifted a 1-0 victory over Reading on the final day of the season as a horrible goalkeeper error by Orjan Nyland gave Harry Cornick an open net to score, earning Luton a play-off place.
In stark contrast, the Terriers finished on a seven-match unbeaten run to earn third place in the table as they seek to take the first steps in a return to the top flight following a three-year absence.
Pelly-Ruddock Mpanzu (ankle) has been ruled out while fellow midfielder Fred Onyedinma (hamstring) is doubtful.
Sorba Thomas has missed the last month of the season with a knee injury while Matty Pearson missed the last seven league games of the season. Both have since returned to training but Friday’s game will come too soon.
Lewis O'Brien has also returned to training after recovering from a hip injury but it remains unclear whether the midfielder will be involved.
Luton Town: Ingram; Naismith, Bradley, Burke; Bell, Campbell, Clark, Lansbury, Bree; Cornick, Jerome
Huddersfield Town: Nicholls; Toffolo, Colwill, Lees, Turton; O'Brien, Hogg, Russell; Holmes, Ward, Sinani
Huddersfield were 2-0 winners to move into third place in the last matchup on April 11th.
The Terriers took the lead just before the hour mark when Jon Russell expertly lobbed in following Pipa's short throw-in.
Naby Sarr made sure of the win in the final minute as he headed in a Thomas corner unopposed at the back post.
The match will be televised live on Sky Sports Football. Coverage begins at 7pm UK time with kick-off set for 7:45pm.