The Gunner's never seemed to gain a foothold in a game which was largely dominated by Eddie Howe's side.
After losing Thursday's North London derby 3-0 to top-four rivals Tottenham Hotspur, Monday's game at St James' Park was a must win one for Arsenal.
Simply not good enough
The Gunners never really got going and looked particularly nervous on the ball and in defence throughout the game.
Aaron Ramsdale made a string of good saves to keep Arsenal in the game, but the loss of Japanese defender Takehiro Tomiyasu on the cusp of half time was a major dent in the hopes of the North London side.
In the second half the Gunners didn't improve and Callum Wilson's shot which was cruelly given as a Benjamin White own goal, felt like the point in the game where Arsenal's task became near impossible.
Bruno Guimaraes 85th minute goal was the final nail in the coffin for Mikel Arteta's men, who before that had sacrificed two of their back four in favour of Alexandre Lacazette and Nicholas Pepe in desperate search of an equaliser.
Monday's game marked the seventh occasion this season where Arsenal had gone a goal down away from home, and were unable to find a way back into the game.
However, it looks as though the red side of North London is set to play Europa League football next season.
Whilst the past season can be looked back on in frustration, with plenty of unnecessarily dropped points throughout it, there are numerous reasons to be optimistic for the future.
Arsenal have fielded on average the youngest side in the Premier League this season, with highly rated youngsters such as Bukayo Saka, Emile Smith Rowe and Gabriel Martinelli (to name just a few) to build their squad around.
Promising manager Mikel Arteta has recently signed a new deal to keep himself at the Emirates for the next three years, which is great news for the club as they will be looking to take the next step of their project over the Summer.
Recruitment will be key during the next transfer window, with the contracts of key players such as Lacazette and Eddie Nketiah set to run out in the coming months.
The squad is set to have a major overhaul, with plenty of transfer business, in and out, to be conducted by Edu Gaspar and the management team.
It will be interesting to see what business Arsenal will complete over the Summer months, and how they will line up at the start of the 2022/23 Premier League season, but before then all eyes remain firmly on the final game against Everton and Carrow Road on Sunday.