The Potters have enjoyed a resurgence in form in recent weeks, with a 1-1 draw against Burnley followed up by 3-1 and 2-0 wins against Sheffield United and Preston North End in the last two games.
Alex Neil's men sit 13th in the Championship table, in touching distance of the top six.
Rotherham, like their hosts, are on their second manager this season after Paul Warne's recent departure to League One side Derby County.
New boss Matt Taylor oversaw two losses and a draw in his first three games before his side secured a 2-1 victory over Huddersfield Town on Saturday.
The Millers are one point behind City in 16th place.
This fixture has seen three draws and one Stoke win in the last four games in recent seasons.
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Team news
Stoke
City have weathered the storm with injuries and now have a number of players back in contention, but still remain without some key men.
Neil has remained coy on the injuries to Jacob Brown, Josh Tymon and Nick Powell, all are likely to remain sidelined this week.
Gavin Kilkenny has been edging closer to a return from a groin injury.
Harry Souttar is back in full training and made his return to action for the U21 side on Monday.
Rotherham
Key man Chiedozie Ogbene faces a scan on Monday to determine the extent of a hamstring injury picked up last week, making him a major doubt to travel to North Staffordshire.
Jamie Lindsay is also ruled out with a face injury after needing stitches last week.
Lee Peltier faces a late fitness test after experiencing hamstring problems in the dying embers of the Huddersfield game.
Peter Kioso remains sidelined with a long-term groin problem.
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Likely lineups
Stoke
Bursik; Clarke, Flint, Wilmot, Fox; Baker, Laurent, Smallbone; Campbell, Gayle, Fosu.
Rotherham
Johansson; Hall, Wood, Harding; Norton-Cuffy, Ferguson, Barlaser, Wiles, Rathbone; Kelly, Washington.
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Ones to watch
Tyrese Campbell
Campbell has been around the first-team setup in the Potteries since 2017, having made his debut in Stoke's 17/18 Premier League relegation season. He found his feet in the first team after Michael O'Neill's arrival in late 2019 and netted six in 16 games in 2020/21 before a serious ankle injury curtailed his progress.
After struggling to find his feet post-injury last season, the arrival of Alex Neil has seen him play a bigger part and command a starting spot. Neil's faith has been repaid after an assist against Sheffield United and goal at Preston saw the 22-year-old play a huge part in his side's upturn in fortunes.
Dan Barlaser
Dubbed the 'Geordie Pirlo' by Millers fans, the 25-year-old midfielder has become a cult hero in South Yorkshire for his role as a deep-lying playmaker over the last three seasons in red. A former Newcastle United youth player, he made three cup appearances for his boyhood club in 2017.
After loan spells at Crewe and Accrington Stanley, he joined Rotherham on loan in 2019 and then permanently the year after. He has netted 16 goals and notched 23 assists as a Millers player and looks to lead the charge as his side attempt to remain in the Championship this time around.
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Match details
Where is the game being played?
The game is being held at the bet365 Stadium in Stoke-on-Trent, Staffordshire.
What time is kick off?
Kick off is at 20:00 BST, on Tuesday, October 18.
How can I watch?
The game will be live on Sky Sports Red Button and Sky Go Extra. It is available on iFollow for overseas viewers.