On Sunday, Liverpool played in their first cup final under Jurgen Klopp, and were hoping to secure a trophy for the club, and the German, during his debut season at the club.
The fairytale story did not have a happy ending though, as the Reds lost the game on penalties, thanks to heroics from back-up keeper, Willy Caballero.
The Argentine saved three of Liverpool’s four penalties, to deny Klopp’s men retaining the trophy they last won in 2012.
As the Reds return to Premier League action, they’ll be hoping to close the gap on Manchester City who are currently in 4th place, nine points ahead.
A win would close the gap to just six points, leaving a chance for a late top four surge.
There are expected to be changes for the game on Wednesday evening, after a few injuries were picked up on Sunday.
Mamadou Sakho was forced off during the cup final, after sustaining a head injury, and remains a doubt to start.
Replacing him could be Martin Skrtel, after he returned to training last week, following a spell out due to a hamstring injury.
The Reds may also be without Daniel Sturridge, after he played the full 120 minutes on Sunday, which led to the injury prone striker suffering from cramp. Also, Lucas Leiva may also miss the match after picking up a muscle injury.
For Manchester City, Yaya Toure is a doubt after picking up a foot injury.
However, Blues boss Manuel Pellegrini has said that ex-Red, Raheem Sterling will start for City, as he prepares to return to Anfield for the first time since his £50million summer move.
Joe Hart is also expected to return to the starting line-up, despite the cup final heroics of Caballero.
This will be the final time Pellegrini will face Liverpool as City boss as he departs from the club this summer, to pave way for Pep Guardiola.
He will hope to add to his trophy collection by keeping up in the title race, and a win could see them go just six points off the top spot.
When the two sides met earlier in the season, Liverpool were triumphant, in an emphatic 4-1 win at the Etihad.
Whilst City are still in the title race, their top four position is far from secure and will be hoping as a minimum to retain Champions League football next season.
There could be plenty of goals in the game tomorrow, as the last nine games between the two sides, in all competitions, have seen 34 goals.
City haven't won at Anfield since 2003, drawing four and losing eight since then.
However, since the turn of the year, Klopp's men have failed to record a home win.