Anthony Martial and Marcus Rashford will lead Manchester United against AFC Bournemouth in the Reds' final Premier League game.
Kick-off is at 3PM (BST) with live coverage from VAVEL UK here.
Schneiderlin dropped as Rooney's in midfield
The full starting line-up was released an hour before kick-off with Martial and Rashford joined in the front line by Jesse Lingard and Juan Mata. Captain Wayne Rooney starts in midfield alongside Michael Carrick with Morgan Schneiderlin dropped from the squad after a poor performance against West Ham United in the league on Tuesday night.
Rooney needs a hat-trick against Bournemouth if he is going to avoid ending the league season with ten or more goals for the first time in his Manchester United career. After a terrible start to the season, he had a good spell in January before a long-term injury ruled him out until recently. He has returned but hasn't netted since that comeback.
Smalling and Blind continue in central defence
Meanwhile, Antonio Valencia keeps his place at right-back with regular Matteo Darmian still injured after a knock against Norwich City last weekend. Chris Smalling and Daley Blind start in central defence once more, their stability and consistency has been key this season although the pair's performance against West Ham, like the majority of the team, was poor.
Marcos Rojo has been omitted from the squad and Cameron Borthwick-Jackson replaces him at left-back, returning to the team for the first time for a while having had an excellent start to his Manchester United career.
Full starting line-up for Manchester United: De Gea, Valencia, Smalling, Blind, Borthwick-Jackson, Carrick, Rooney, Mata, Lingard, Martial, Rashford
With Borthwick-Jackson and Rashford in the starting line-up as well as Andreas Pereira and Guillermo Varela on the substitutes bench, it is the 3,802nd consecutive first team United game with an academy product in the squad, a record stretching back to 1937.
Substitutes for Manchester United: Romero, Jones, Varela, Young, Herrera, Pereira, Memphis.