A trip to Arsenal will not brighten any spirits at Middlesbrough, with the club having not won in seven games, but Aitor Karanka's side will head South and hope to cause an upset at the Emirates.
Leadbitter aiming to make first Premier League start in seven years, with Ramsey set to return for the hosts
Arsenal's only injury worry going into the match is Spanish playmaker Santi Cazorla. He missed numerous games last season with an achilles injury and could be replaced in the starting lineup by Aaron Ramsey who returned to fitness this week.
Middlesbrough, on the other hand, will be testing the fitness of captain Grant Leadbitter, who trained with the squad ahead of the game with the Gunners.
Leadbitter will be looking to start his first Premier League game in seven years after his transfer from Sunderland to Ipswich Town in 2009, but this match may just be too soon for the midfielder to make his return.
Calum Chambers, who has started in all three of Middlesbrough's games since joining on loan, cannot play against his parent club due to the terms of his loan agreement. Daniel Ayala is likely to start his fourth league game of this campaign in place of him.
Adama Traore came off the bench in Middlesbrough's last game against Watford and completed the most take-ons in the match. The former Barcelona winger will be hoping to make his first Boro start against Arsenal.
Arsenal dominate recent head-to-heads
The recent fixtures between Arsenal and Boro severly favour the side from North London.
Middlesbrough 'keeper Tomas Mejias impressed during the last meeting between the sides, which eventually finished 2-0 to Arsenal thanks to a brace from Olivier Giroud.
The most notable meeting between the sides, of late, was Middlesbrough's 7-0 loss to Arsenal at Highbury. A very forgettable day for fans of the Teesside outfit ten years ago, as well as 'keeper Brad Jones, who saw Thierry Henry score a hat-trick past him.
Middlesbrough: Valdes; Barragan, Ayala, Gibson, Friend; Clayton, Forshaw; Traore Ramirez, Downing; Negredo.
Arsenal: Cech; Bellerin, Mustafi, Koscielny, Monreal; Coquelin, Ramsey; Walcott, Ozil, Sanchez; Giroud.