Southampton come into the game after returning to winning ways last weekend away at Stoke City where they won the game 2-1. Two goals from Graziano Pelle got an all-important win for the Saints at a crucial time in the season and now they will want to build on that result.
Liverpool on the other hand under Jurgen Klopp are flying and will be brimming with confidence after coming through a tough Europa League tie against big rivals Manchester United in midweek. The red's have also won three straight Premier League games and will be confident of adding a fourth to that run.
Southampton before their win last weekend had gone three successive games without a win. In January after the saints won at Old Trafford it was seen that they could mount a challenge for Europe but that looked like it wasn't going to happen. The recent win now though will give the team the momentum to try and achieve it still.
The Saints come into the game in seventh position eight points of a top four place while Liverpool are also on the same number of points in eighth place but they have two games in hand over Southampton.
The crowd at St Mary's will be key to trying to get their team going and get a big victory that will put a bit of space between them and Liverpool.
Earlier in the season at Anfield, the two sides played out a 1-1 draw with goals coming from Christian Benteke and Sadio Mane. The two sides have also met at St Mary's this season in the Capital One Cup when Liverpool won the game 6-1 with a Dirvok Origi hat trick. In terms of the Premier League, Liverpool won the game 2-0 last season at St Mary's with goals coming from Philipe Coutinho and Raheem Sterling.
The saints will be without Charlie Austin due to a hamstring injury but the striker is set to be available after the International Break. Florin Gardos is also not available after only returning to training after a long-term injury and is likely to not be ready for another three weeks.
The good news for Ronald Koeman is that Jay Rodriguez is on the mend but will once again play for the U21s this weekend to help him with his fitness.
Victor Wanyama and Jose Fonte are both available for the game after suspension which is great news for the team as they are two big players.
The Reds will be without Danny Ings and Joe Gomez who are out until the end of the season with knee injuries.
Alberto Moreno is a doubt for the game after suffering a hamstring strain in training before the game with United in midweek were he missed that game as a result of it.
Apart from that Liverpool have most of their other senior players fit and ready to defend a good lead from the first leg.
Southampton will host Liverpool at St Mary's in the Premier League on Sunday, March 20th with kick-off at 1.30 PM BST.