Palace enter the clash without winger Yannick Bolasie, who completed his move to Everton earlier this week for the sum of £25million, whilst work is still being done to bring Liverpool's Christian Benteke to the club, possibly using funds generated by the Bolasie deal.
Neither side won on the opening day
Neither side managed a win on the opening day, although Spurs did the better - drawing 1-1 away at Bolasie's new club, Everton. Ross Barkley had given the Toffees the lead at Goodison Park in the first half, but Spurs battled back through Erik Lamela, who headed in to level things up. One setback was captain and goalkeeper Hugo Lloris hobbling off, scans confirming that he'll be out for a month with a hamstring injury.
Palace fared even worse, going down 1-0 at the hands of their old manager, losing at home to Tony Pulis' West Bromwich Albion side. That game, not one for the history books, looked like it was easing along to a scoreless draw, only for Salomon Rondon to strike a 74th minute winner.
Alan Pardew's side will be hoping for better fortune in front of goal this week, especially after learning that it's Michel Vorm, rather than Lloris, in the Tottenham goal.
Elsewhere in the Lilywhites' camp, Moussa Dembele is still serving a suspension whilst Son Heung-Min has returned to training following representing South Korea at the Rio Olympics. Kevin Wimmer is also a doubt with a hamstring injury, although he'd have likely only made the bench anyway.
Palace have one of the worst injury records in the division as it stands, with no more than seven players in danger of missing Saturday's game. Amongst those is new signing James Tomkins, who has a hamstring strain. The rest of those on the treatment table includes the likes of James McArthur, Bakary Sako, Jordan Williams and Fraizer Campbell.
Can Alli repeat his magic?
Tottenham fans will be hoping to see a replay of Dele Alli's sensational goal from the last meeting between these two teams on Saturday. With the game tied at one all after Harry Kane cancelled out Jan Vertonghen's own goal, Alli decided things with a masterful bit of skill and then finish before Nacer Chadli made it 3-1 deep into stoppage time.