Reports suggest that Mauricio Pochettino and those around him will look to land the signing of the Spaniard by next summer at the latest, if not in January, providing they can agree a fee with Real.
Isco now struggles for gametime
Since joining in 2013 from Malaga, Isco has struggled to make the impact that many expected he would at the Bernebau after a promising start, having often been behind the likes of Luka Modric and Toni Kroos in the pecking order.
Now 24-years-old, he's entering the prime of his career and seems determined not to let it waste away on the bench in Madrid.
Tottenham made tentative enquiries in the summer, however it was deemed that he'd be too expensive at the time, and Isco was prepared to give it one more season at Real Madrid, whilst Pochettino was content enough with his attacking midfield options.
Could January be his time to move?
However, having made just two appearances so far this season, noises from the Spaniard's camp regarding wanting a move away are increasing, and Spurs are in pole position to pounce as they look to lure him to the Premier League.
One criticism of Tottenham's squad this season has been that although they're well rounded across the pitch, they can sometimes lack the star quality to make the difference in a game. Signing Isco, who only has less than two years remaining on his Real Madrid contract, would certainly change that.
A deal that would see Isco leave on loan in January, before departing permanently in the summer, has been mentioned, and if he became readily available then you'd imagine Spurs wouldn't take too much time to make up their minds.
The thought of Isco lining up alongside the likes of Christian Eriksen, Dele Alli and Harry Kane is a frightening one for Premier League defences, and one that could become a reality in the not so distant future.