Tony Pulis' men make the trip to the league leaders following Saturday's thrilling win versus Crystal Palace, at The Hawthorns. In that game, the the home side held off a second-half fight back from a plucky Eagles side.
Tall task for Foxes
West Brom's task however, will be a tough one. Leicester's unrelenting chase towards a unimaginable league title continues a-pace, with The Foxes leading the chasing pack at the summit of the league by five points, which could become eight by the end of play on Tuesday.
After Leicester scrapped a one-nil wins versus a valiant Norwich City, a late Leonardo Ulloa goal gave Claudio Ranieri's men a vital three points.
Baggies will sense an opportunity
As the final run-in approaches, there are signs that the champions elect are starting to feel the heat, in unchartered waters. West Brom are likely to be equally resistant to the likes of Jamie Vardy and Riyad Mahrez.
Since however, reinstalling Saido Berahino to the staring XI, West Brom have begun to display more of an attacking aesthetic to their game. Should Pulis utilise a similar tactic on this occasion though, a defeat is the likely scenario.
Leicester will be without key man N'Golo Kante who has played every minute since September and has been a driving force in the Foxes' engine room. Kante's absence is a boost for West Brom, who despite being well clear of the drop zone, will look to put the cat amongst the pigeons at the top of the table.
West Brom keen to turn the tables
When the sides last met on Halloween, Leicester came out on top courtesy of a brace from Mahrez and Vardy's decisive third goal.
As relative newcomers to the English top flight - despite the host's lofty perch - both Leicester and West Brom are more familiar with one another at Division 1 or Championship level.
Since 1994, the sides have met on 16 occasions in all competitions. Intriguingly, in terms of league competition, both are tied at six wins a-piece - although Leicester edge their Premier League record by tow to one.
Leicester, as documented, will be without their French midfield dynamo N'Golo Kante, who suffered a hamstring strain at Carrow Road at the weekend.
Matty James is a long-term absentee with an ACL knee injury.
Tony Pulis will also be without key personnel. Chris Brunt sustained a knee injury and is now a doubt for Euro 2016 with Northern Ireland.
Midfield duo James Morrison and Callum McManaman are nearing a return to action, but the game will come too soon once more.