Santon will be heading to West Ham after Inter and the Hammers agreed to a season-long loan deal worth €550,000.
Slaven Bilic's side also have an option to buy the Italian at the end of the loan with the price being set at €5.9 million, according to reports from SBNation.
Third time is a charm
With the deal between Inter and West Ham set to be completed, it appears that Santon will finally be making his move away from the San Siro.
Earlier in the summer transfer window, Santon was set to move to West Ham's fellow Premier League side Sunderland AFC for a fee of €6 million.
However, talks between Santon and Sunderland broke down after the club wanted to add a clause into the player's contract that would see Santon's wages plummet if Sunderland were relegated in the upcoming season. Upon Santon refusing to agree to the clause, the deal was scrapped.
Following the collapsed Sunderland deal, Santon appeared to be leaving Inter Milan once again, but to fellow Serie A side Napoli. Initial speculation surrounding the failed transfer was centered on Santon's knee concerns.
However, it was revealed that Napoli President Aurelio De Laurentiis felt Santon lacked the characteristics he wanted for his team.
In the days leading up to West Ham making a move for Santon, the Hammers were searching the transfer market for a new left-back after losing standout left-back Aaron Cresswell for up to four months to a serious knee injury.
The 26-year-old defender suffered ligament damage in his left knee after undergoing a two-footed tackle from opposition in preseason.
Some reports have suggested Cresswell will report to a specialist in London to determine whether or not he requires surgery.
In an interview with the club's website, West Ham's medical chief Stijn Vandenbroucke said regardless of what path the club and Cresswell take regarding the injury, the player will need to ensure he is rested and healthy before he returns.
He explained: "Whatever course of action we decide to take, Aaron faces a period of rest, followed by treatment and rehabilitation and he will be out for a period of between three and four months."
Cresswell was one of West Ham's better players this past campaign, contributing two goals and four assists last season for the Londoners. To make matters far worse, the depth at the position is very limited.
According to the Evening Standard, current West Ham players Angelo Ogbonna, Harvard Nordveit and Sam Byram were thought to be potential replacements, but the left-back spot was not their natural position, with Santon considered a better option.
What's next for Santon and West Ham?
West Ham will be back in action on August 4 in the UEFA Europa League against N.K. Domzale in the team's first match at the new Olympic Stadium, needing to win to ensure their progression to the next round.
West Ham will then be kicking off their 2016-2017 Premier League campaign away at Chelsea on August 15.