Goals from Adam Maher, Luciano Narsingh and Jurgen Locadia ensured that PSV's convincing start to the season continued, despite Jeffrey Bruma's sending-off.
PSV needed a good result following their poor showing in Russia on Thursday night, but newly-promoted Excelsior were never going to put up the same sort of fight as Dinamo Moscow and PSV dominated.
Adam Maher broke the deadlock just over half an hour into the game, after putting in a tricky cross which no-one could seem to get a touch to and it found it's way into the bottom corner.
Luciano Narsingh doubled the lead right before half-time when he poked home Jurgen Locadia's through ball. Then, provider turned scorer when Locadia smashed home Florian Josefzoon's cut-back on 51 minutes.
The event was somewhat spoiled by Jeffrey Bruma's red card offence, but it was deserved, as he pulled down an Excelsior striker on the counter-attack. Phillip Cocu, the PSV boss, was alsp sent to the stands for his arguments with the decision.
The win keeps them top of the Eredivisie going into the international break. For Excelsior, however, they move down to 12th place.