The Arsenal man, who spent the season gone on loan in Italy with Roma, picked up a thigh injury in the 1-0 win over Northern Ireland - Arkadiusz Milik's strike the difference in Group C's opening fixture.
Because of this, he missed Tuesday's training session, with his brother Jan telling Polish TV that he'd be surprised to see Szczesny on the pitch against Germany.
Those fears have now been confirmed, with Adam Nawałka to be forced to make a huge change in his back five tomorrow despite them keeping a clean sheet, something he will not be overly happy about given the chemistry shown in defence in their first outing - even if they weren't challenged too much.
Speaking to UEFA this week, Grzegorz Krychowiak - man of the match on Sunday - was optimistic about the chances of Szczesny playing a part against the Germans.
"It is getting better with Wojciech," he said. "He has started to walk normally already."
However, the potential of him featuring has now been put to bed completely - though Krychowiak is not all too concerned. When the Arsenal man was a doubt, he said he "hope[d]" he'd be able to play, but added that it does not matter if not as Poland "have other great goalkeepers."
Plenty more options
The Sevilla midfielder is right too. Behind Szczesny in the pecking order are two Premier League starters - Swansea City's Lukasz Fabianski and Bournemouth's Artur Boruc, both of whom are first choice at their clubs.
Both have had terrific seasons and have plenty of experience at international level, with the recipient of the starting berth at Euro 2016 unknown in the build-up.
Now, Nawałka has to choose between the two though, who are sure to have been trying their best to impress in training following the knock to their fellow goalkeeper.
Whether the starter tomorrow will be in between the sticks in the final group game with the Ukraine, however, is uncertain as the manager believes Szczęsny will be fit when the fixture comes around.