A win assures passage into the last 16, while defeat for Northern Ireland against Germany in the other fixture would take the pressure completely off Adam Nawałka's men as they would go through with a win, loss or draw.
However, despite opponents Ukraine being the only side with no chance of qualification to the next round, Poland are not taking them lightly.
Goalkeepers Artur Boruc and Lukasz Fabianski spoke to the media about the prospect of facing Group C's bottom side, as did assistant coach Hubert Małowiejski.
The latter set the tone, saying: "I don't agree [Ukraine] play for nothing. They play for honour, what is important."
Małowiejski continued, saying that Poland are "prepared for a very dangerous opponent" who have plenty of talented players.
The performances of Biało-czerwoni's defence have been impressive recently though, and so they will take confidence into Tuesday's game despite the threat posed by the likes of Yevhen Konoplyanka and Andriy Yarmolenko.
Fabianski, who kept a clean sheet last time out in Wojciech Szczęsny's absence, says that this is down to simple research. He told the media: "We have lot of information about the opponents from our information bank and thanks to that, we know better how to neutralise them."
Meanwhile, fellow goalkeeper Boruc believes: "It's Ukraine who should be more worried about us than the opposite."
He is, however, "surprised" by their poor results so far, adding: "They have good players, especially on the wings, but for some reason they have not been able to show it”.
Szczęsny to miss out, again?
Fabianski and Boruc could be battling it out for a starting spot once again this week it seems, with Szczęsny a doubt for the game.
The Arsenal 'keeper, who spent this past season on loan with Roma, picked up a thigh injury in the opening 1-0 win over Northern Ireland, meaning he missed the goalless draw with Germany last time out.
It was Swansea City's Fabianski who took his place, and he impressed as he helped his side keep the world champions at bay, making him the favourite to step in once again if required.
Małowiejski provided an update on Szczęsny's injury, saying: "We don't know yet whether he will be fit for Ukraine or not. Our specialists work with him but nothing can be declared at the moment."
Meanwhile, Boruc also gave his thoughts on being third-choice in the squad, despite his superior experience - the 36-year-old boasting more international caps than his two competitors for a place put together.
“It is not easy to be on the bench," he admitted, but he says it's "slightly easier" to accept given that both Fabianski and Szczęsny are "top class" stoppers.