The Italian was known to few heading into the tie, but he certainly won a few fans in his time on court with the talented Aussie, such was the stylish manner with which he played.
However, Kyrgios showed plenty of quality to match and then better his opponent's, edging Cecchinato out with a 7-6 7-6 6-4 victory, with him heading into the second round at Roland Garros having been well-tested early on, which is always a good thing.
He will now face lucky loser Igor Sijsling in his next match, who beat Romanian qualifier Adrian Ungur 6-1 6-2 7-6 earlier today.
Kyrgios pushed all the way in entertainer opening set
One of the first matches of this year's French Open, Kyrgios showed his class from the off in this clash, despite the conditions perhaps favouring his opponent.
Cecchinato may have been hoping that the surface, plus the ongoing rain, would give him a little more time to deal with the Aussie's powerful serve, but the chances of that happening were quickly put to bed when Kyrgios raced through his opening service game in a matter of seconds.
The Italian, however, held his own in his service games, despite being put to the sword on a couple of occasions - particularly early on.
The man ranked 124th in the world grew into the match too, and proved difficult for Kyrgios to break down as the first set moved into a tiebreak after some high quality tennis from both men.
Whether Cecchinato, an unknown quantity to Kyrgios and the spectators alike, was simply rising to the occasion or showing the potential that he has, but hasn't yet fulfilled at 23-years-old, he was certainly giving the Aussie a run for his money as he registered an early mini-break.
However, Kyrgios showed why he is ranked amongst the world's best as he clawed back the deficit and clinched a fascinating opening set in his typically fierce but stylish manner.
Cecchinato continues to push, but the Aussie conquers once more
After such a close opening set, the second was always going to be pivotal in the match. If Cecchinato was to get back into the affair, he needed to take the setback on the chin and fight back to level the scores, but if he did start feeling sorry for himself then any chance of victory was going to quickly evaporate.
The early signs were of the latter as Kyrgios brought real momentum into the set with him, forcing three break points in his opponent's first service game. However, the Italian fought back with real composure - with a delicious drop shot the pick of a confident handful that saved the points.
After this, the set continued in the same manner as the first - both men playing their part in a truly enthralling match of the highest quality.
In truth, Cecchinato never looked like breaking Kyrgios, with the Aussie's serve too strong. A tiebreak seemed his best bet of clinching a set, or a capitulation by his opponent - which does occur with the 21-year-old at times.
Kyrgios, meanwhile, continued to ask questions of the Italian, earning set points on his serve at 5-4. Every time though, Cecchinato responded perfectly under pressure as we again moved towards another tiebreak.
An astounding service game from the underdog, which was capped with an incredible lob, made it 6-6, as he headed into the tiebreak with a spring in his step to earn himself two set points.
Kyrgios stood tall though and worked hard to save both opportunities, with the tension building as the uncertainty as to the victor of set two grew.
However, moments after keeping himself in the set, the Aussie would make it his - a lovely shot down the line putting him into a 2-0 lead, and a huge step closer to round two.
First break point taken as Kyrgios claims the win
Despite the scoreline, Cecchinato continued to show resilience as we started the third set, with him fighting to stay in the tournament now.
It remained an even match as the games ticked by, neither able to break. However, on his 13th break point of the match, Kyrgios finally breached the Italian's serve to take the lead in the set - one consolidated by a strong and quick service game to make it 4-2.
It was a double fault that gave the Aussie the advantage and it seemed to take the wind out of Cecchinato's sails a little, denting his confidence as he edged nearer to defeat.
He continued to pull shots out of the bag that received warm applause from the stands, graciously bowing out of the tournament. In all though, he lacked the urgency and tenacity to break his opponent and get back into the match, something he failed to show in the first two sets as well, with him unable to push himself to better Kyrgios.
The 21-year-old comfortably saw out his final service games of the match, not needing to push himself to break either as he steadily walked the path to victory.
The win was sealed as Kyrgios came out on top in a rally from the baseline, his usual dominant self with plenty of hard-hitting - forcing Cecchinato to smash the ball into the net as his French Open came to a premature end.