Day six of the French Open was dominated by the news of nine-time champion Rafael Nadal's withdrawal due to a wrist injury, but also featured some surprise results as seeded players met for the first time during the tournament. Here's a roundup of all the results from Friday at Roland Garros.
Murray finally finds form
Andy Murray was in action against 37-year old Ivo Karlovic, and there were perhaps doubts over Murray's ability to come through the match after two long struggles in the opening rounds, and with Karlovic's colossal serve a highly dangerous weapon. However, the world number two was a different player, and dispatched his veteran opponent in straight sets, breaking his opponent three times and winning 34% of points on return. Murray will be pleased to get a quick victory after two five set marathons, and should take the win as a confidenc boost as we begin to move into the business end of the tournament.
For defending champion Stan Wawrinka it was a similar story, 30th seed Jeremy Chardy unable to take a set off the world number four. The Swiss looks to be playing himself into form through the early rounds, and will face Victor Troicki for a place in the quarterfinals, after he defeated Gilles Simon on Friday.
Elsewhere, there were wins for Milos Raonic, Kei Nishikori and Richard Gasquet, who put out Nick Kyrgios in straight sets.
Muguruza continues to impress
Garbine Muguruza led the WTA elite into round four with a 6-3 6-0 win over Yanina Wickmayer. The Spaniard broke serve six times on her way to another highly impressive victory, and looks in superb form as she moves into the second week. The world number four has reached the last four in both the last two years in Paris, and will be looking to build on those results this time around.
The biggest shock of the day was Petra Kvitova falling victim to world number 108 Shelby Rogers, 6-0 6-7 6-0. Kvitova has only reached the last eight once at a Grand Slam event since her second Wimbledon title in 2014, and her struggles have continued in Paris. The former world number two looks likely to drop out of the top ten after the tournament.
Sam Stosur was a surprise three-set victor over last year's finalist Lucie Safarova, defeating her 6-3 6-7 7-5. The veteran Australian will face Simona Halep for her first Grand Slam quarterfinal place since 2012.
Elsewhere there were wins for Halep, Svetlana Kuznetsova and Agnieszka Radwanska, but defeat for Sloane Stephens.
 Andy Murray d.  Ivo Karlovic, 6-1, 6-4, 7-6(3)
 Stan Wawrinka d.  Jeremy Chardy, 6-4, 6-3, 7-5
 Kei Nishikori d. Fernando Verdasco, 6-3, 6-4, 3-6, 2-6, 6-4
 Milos Raonic d. Andrej Martin, 7-6(4), 6-2, 6-3
 Richard Gasquet d.  Nick Kyrgios, 6-2, 7-6(7), 6-2
 John Isner d. Teymuraz Gabashvili, 7-6(7), 4-6, 2-6, 6-4, 6-2
 Viktor Troicki d.  Gilles Simon, 6-4, 6-2, 6-2
Albert Ramos-Vinolas d.  Jack Sock, 6-7(2), 6-4, 6-4, 4-6, 6-4
 Agnieszka Radwanska d.  Barbora Strycova, 6-2, 6-7(6), 6-2
 Garbine Muguruza d. Yanina Wickmayer, 6-3, 6-0
 Simona Halep d. Naomi Osaka, 4-6, 6-2, 6-3
Shelby Rogers d.  Petra Kvitova, 6-0, 6-7(3), 6-0
 Samantha Stosur d.  Lucie Safarova, 6-3, 6-7(0), 7-5
 Svetlana Kuznetsova d.  Anastasia Pavlyuchenkova, 6-1, 6-4
Tsvetana Pironkova d. No.  Sloane Stephens, 6-2, 6-1
 Irina-Camelia Begu d. Annika Beck, 6-4, 2-6, 6-1