The Dons have found themselves sitting in the relegation zone, after a season full of ups and downs including lots of inconsistency. It's tight down at the bottom of the Sky Bet League One table and one result can change a lot for teams around them.
Meanwhile, the Brewers have won four games in a row and do not look like slowing down after beating title chasing Peterborough United this past weekend.
Jimmy Floyd Haselbaink's side look like a completely different side since the Dutchman took over at the turn of the year.
In what is set to be a relegation six pointer for both sides, it's going to be a hell of a battle as both are fighting for every point.
Mark Robinson has no fresh new injury concerns other than Ethan Chislett who missed the game at the weekend is set to take a late fitness test hoping he can play. It'd be a huge boost for the Dons if the attacking midfielder can play.
Meanwhile for Burton, the only player on the sideline for them is Kieran Wallace who is set to be out for a long period of time after suffering an ACL injury.
Also, the Brewers will be happy to have loanee Ryan Broom back as he couldn't play against the Posh as that is his parent club. Sean Clare will also be back for the away side as he comes back from suspension.
AFC Wimbledon - 4-2-3-1
Walker; Guinness-Walker, Nighingale, Heneghan, Johnson; Dobson, Woodyard; Longman, Chislett, Rudoni; Piggot
Burton Albion - 4-2-3-1
Garratt; Brayford, Carter, Bostwick, Hamer; Edwards, Mancienne; Smith, Rowe, Akins; Hemmings
Ones To Watch
Joe Pigott - AFC Wimbledon
The 27-year-old is quick on the ball and can use his pace to burn off defenders, on his day he'll be a problem, so Dons fans will hope they get their top scorer in scoring form when they welcome a stubborn Burton to Plough Lane.
Hayden Carter - Burton Albion
The 21-year-old signed for the Brewers in January from Blackburn Rovers and ever since signing he's been a breath of fresh air to the ageing Burton defence.
It was key for Burton to get a replacement following the unfortunate loss of Sam Hughes at the end of last year, who was sidelined for a 'long time' with a knee injury, he went back to his parent club Leicester City so he could start his recovery process.
Burton looked lost at the back, Carter has brought youth and pace to the backline and even helped out scoring a goal in the weekends win against Peterborough.
He's certainly one for the future and this Burton side is the perfect place for him to grow playing alongside experienced players such as Michael Bostwick and club captain John Brayford.
How To Watch
Due to current lockdown restrictions, there will be no fans in attendance and the game can be watched via iFollow where passes can be purchased on club websites for £10. Kick-off is scheduled for 19:00 GMT.