The U's are looking for a fourth successive win on the road as they aim to finish in the top of the table in what has been a wildly successful return to the third tier.
For the Black Cats, they are level with Wycombe for the final play-off spot with three matches remaining in their quest to escape League One, where they have resided for four years.
Alex Pritchard is expected to be available for selection after training with the club over the past week and just missing out on the Black Cats' last match.
Callum Doyle could be back in contention following illness, with Ron-Thorben Hoffman also back training following a similar issue. Leon Dajaku remains out.
Harrison Dunk will miss the final two matches of the season after splitting his shin. Sam Sherring is also likely out until next year.
Sunderland: Patterson; Cirkin, Wright, Winchester; Clarke, Matete, Evans, Embleton, O'Nien; Stewart, Broadhead
Cambridge United: Mitov; Iredale, Okedina, Jones, Williams; Digby, May; Brophy, Knibbs, Smith; Ironside
Ones to watch
Dan Neil (Sunderland)
The midfielder was nominated for the EFL League One Young Player of the Season award, having enjoyed a fine season that has seen him register four goals and eight assists in 42 appearances.
Sam Smith (Cambridge United)
He's scored in the U's last two victories, including the match-winner against relegation-threatened Morecambe and looks to finish the season strong.
In November, Sunderland came away with three points on the road courtesy of a Nathan Broadhead strike to seal a 2-1 victory.
On 15 minutes, the visitors were in front when a corner by Pritchard fooled everyone and went in off the far post, Dimitar Mitov credited with an own goal.
Cambridge leveled 12 minutes later as Sam Smith finished off a neat move with a low shot that beat Hoffman at his near post.
The Black Cats found a winner as Broadhead swiveled before he fired into the top corner from outside the box, leaving Mitov with no chance.
The match will not be shown on live television. Coverage is available and Cambridge's iFollow channel while Sunderland will offer live audio commentary as well their Twitter and Instagram accounts.
Kick-off is set for 3pm UK time.