The visitors come into the game on the back of a heartbreaking last-minute defeat to Derby County.
Gary Rowett could be without six first teamers when the two sides meet on Saturday as Ryan Leonard, Connor Mahoney, Shaun Williams, Murray Wallace, Maikel Kieftenbeld and Kenneth Zohore were all left out of their last game. There are also worries over the fitness of Jake Cooper after he was forced off in their win over Birmingham.
Alex Pearce replaced Jake Cooper in the 22nd minute and he could keep his place in the side on Saturday.
It is therefore likely Ainsworth will stick with the same 11 for their trip to The Den.
Bialkowski, Romeo, Hutchinson, Pearce, Evans, Malone, Woods, Thompson, J.Wallace, Smith, Bennett.
Wycombe Wanderers (4-3-3)
Allsop, Grimmer, Stewart, Tafazolli, Obita, Wheeler, Knight, Mehmeti, Horgan, Ikpeazu, McCleary.
Ones to watch
Jed Wallace - Millwall
The influential winger scored his seventh goal of the season for The Lions, and once again is on course to hit double figures for goals this season.
The ex Wolverhampton Wanderers player has been the key to Millwall's success over recent years, and is always a dangerous player and always one for the opposition to watch out for.
Fred Onyedinma - Wycombe Wanderers
Fred Onyedinma signed for Wycombe in the summer of 2019 after a successful loan spell from Millwall was made permanent.
This weekend the winger comes up against his former club and will definitely want to have an impact, especially as he is returning to face some of his former team mates.
The two sides last met in October at Adams Park where Millwall edged Wycombe 2-1. Goals from Ryan Leonard and Jed Wallace cancelled out a Scott Kashket opener. The last five meetings between the sides, Millwall have just edged with them winning three compared to Wycombe's two.
How to watch
Due to the current national lockdown, there will be no fans in attendance at The Den. This means the game is available on iFollow through Millwall and Wycombe's respective club websites, with passes priced at £10.
The game kicks off at 15:00 GMT on Saturday 20 February 2021.