Both sides come into the rearranged fixture, originally supposed to be played in January, having suffered an inconsistent runs of from since the new year and will be desperate to prevent their seasons from fizzling out.
Three points for the hosts could see them move back up to ninth place in the League two table, while a victory for Orient may bring them into serious play-off contention potentially moving just six points off seventh place with a game in hand.
United will be without Centre-back Rod McDonald after the 28-year-old was shown a red card during defeat against Stevenage at the weekend.
Other than this suspension however, Chris Beech's side will be at full strength having not picked up any new injuries in their previous game.
Norman; Tanner, Bennett, Hayden, Armer; Riley, Guy, Mellish; Dickenson, Zanzala, Patrick.
Vigouroux; Akinola, Turley, Happe, Widdowson; Clay, Cissé; Wilkinson, Kemp, McAnuff; Johnson.
Ones to watch
The 23-year-old has been a revelation in Cumbria this season, having made the permanent jump into midfield he has quickly become a main stay in the Carlisle line up.
His 11 league goals make him the teams top scorer and undeniably their most dangerous attacking threat.
Mellish's ability to carry the ball from the deep and make dangerous attacking runs has been a highlight of the Blues play when going forward.
The Englishman has become possibly the most important and influential player on the pitch for Chris Beech's team this season, and he could well find himself on the shortlist for a number of higher league teams this summer.
Johnson's impressive 16 goals so far this season have seen him become the focal point of the Orient attack.
The 26-year-old can play anywhere across the front three and his work engine style of play makes him a handful for any defence he faces.
If Carlisle are hoping to have any chance of keeping a clean sheet against Jobi Mcanuff's side then isolating and cutting of Johnson will be crucial.
How to watch
The game will begin at 19:00 Tuesday March 23.
Due to current restrictions as a result of the Coronavirus pandemic no fans will be able to attend the game in person.
The match can be viewed for a price of £10 however through the iFollow service which can be accessed through either Carlisle United or Leyton Orient's official website.