Meanwhile for Burton, after picking up a huge win against Swindon Town this past Monday, they moved further adrift of the drop zone. This will give Jimmy Floyd Haselbaink confidence of survival going into the last eight games with most results going their way.
With their impressive unbeaten away record since Haselbaink and Dino Maamria came in, they'll be up for the challenge of Fratton Park.
Paul Downing came off at half-time in Monday's game for the hosts, so it's likely he will miss out this time around, as the Cowley brothers won't want to risk having the defender out for longer than what they would have liked.
They also will have a late fitness test on Sean Raggett, who fractured his cheekbone against the Latics. The former Blackburn man will possible make the bench against The Brewers.
Meanwhile, the visitors have a full squad to choose from and will be expected to be unchanged.
Portsmouth - 4-4-2
MacGillivray; Brown, Whatmough, Nicolaisen, Brown; Jacobs, Naylor, Close, Harness; Williams, Curtis
Burton Albion - 4-2-3-1
Garratt; Bostwick, Mancienne, Carter, Brayford; Clare, Smith, Akins, Rowe, Wallace, Hemmings
Ones to watch
Marcus Harness - Portsmouth
With this being his most prolific season for the Hampshire side, he has scored eight goals and assisted nine. Harness has been a real asset for them and a key in Pompey's league position
Having spent most of his career at Burton, he will be eager to impress when facing them.
The winger has blistering pace and can play on both sides, and will be sure to pose a threat to the Brewers full-backs.
Tom Hamer - Burton Albion
After young Tom Hamer scored his first Burton goal on Easter Monday against Swindon, he is deservedly getting a special mention.
Since signing in January, he has brought in an extra goal-scoring threat, from left-back. With his long throw-in the 21-year-old causes havoc in the opposition's box every time he gets the opportunity.
When the sides met back in October at The Pirelli Stadium, Portsmouth won 4-2, Harness scored a hattrick.
How to watch
Due to current restrictions in the UK, there will be no fans in attendance at Fratton Park. However, the game is available to watch on iFollow. The kick-off is at 15:00 BST.