Guiseley will hope to pull away from the National League North relegation spot as they host Brackley Town in a Tuesday night fixture.
The Lions have lost two on the bounce, losing 3-0 to York City and 2-0 to Hereford at the end of a run of games that has seen the Yorkshire outfit fall to 21st in the table.
On the other hand, Kevin Wilkin's side are nine unbeaten and are looking to close the gap on first place Gateshead, with the Saints having two fixtures in hand.
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Team news
New loan signing from Mansfield Town James Gale could make his Lions debut in this fixture. Fellow loan men Thierry Latty-Fairweather and Jason Sraha have both had their deals extended.
David Bremang has returned to Barnsley following his month deal at Nethermoor and Prince Ekpolo will be unavailable following his red card against York at the LNER Community Stadium.
The Saints have no real concerns as, despite his dismissal at Southport on Saturday, Max Dyche should be available for the visitors with it taking the National League seven days to process red cards.
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Predicted lineups
Guiseley: Mason, Sraha, Hollins, Bencherif, Latty-Fairweather, Brown, Tear, Cantrill, Hutchinson, Gale, McLean
Brackley Town: Lewis, Cullinane-Liburd, Dyche, Murombedzi, Lomas, Dean, Lowe, Armson, Ndlovu, York, Walker
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Ones to watch
Always a threat, Guiseley will have to attempt to keep Lee Ndlovu off the scoresheet. The Brackley front man has scored ten this season and will be looking to add to his tally in Yorkshire.
Formerly of Halifax Town, Dom Tear scored a brace for Guiseley in their 3-2 win over Alfreton Town and with the Lions boasting the worst attack in the league the midfielder who spent loan spells at Blyth Spartans and Buxton previously may be the best bet to get a home goal.
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Previous meeting
It was revenge on Guiseley for knocking them out of the FA Cup earlier in the season as the Saints secured a 1-0 win at St James Park in December.
A Matt Lowe goal inside the first fifteen minutes was enough to keep all three points in Northamptonshire.
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How to watch
Tickets for this National League North fixture can be bought in advance on Guiseley's ticketing website or at the ground.
There will be no livestream but commentary will be available from the hosts, with details on their social media.
Live game feeds are on both sides' twitter accounts as well as build up and reaction.
Kick off at the Nethermoor is 19:45 GMT.